|Murabutide||Unit size||Cat. code||Docs||Qty||Price|
Synthetic derivative of muramylpeptide
NOD2 Agonist - Synthetic derivative of muramyldipeptide
Murabutide is a safe synthetic immunomodulator derived from muramyl dipeptide (MDP), the smallest bioactive unit of bacterial peptidoglycan. In contrast to MDP, murabutide is devoid of pyrogenic activity  and lacks somnogenic activity .
Murabutide has the capacity to synergize with selected therapeutic cytokines to drive the release of Th1 cytokines. Murabutide has been found to suppress human immunodeficiency virus type-1 (HIV-1) replication, in macrophages, through a regulated expression of cellular factors needed at different steps in the virus replication cycle . Murabutide does not transduce the signal through TLR2 nor TLR4 .
1. Chedid LA. et al., 1982. Biological activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenicity. Infect Immun. 35(2):417-24.
2. Krueger JM. et al., 1984. Muramyl peptides. Variation of somnogenic activity with structure. J Exp Med. 159(1):68-76.
3. Darcissac EC. et al., 2000. The synthetic immunomodulator murabutide controls human immunodeficiency virus type 1 replication at multiple levels in macrophages and dendritic cells. J Virol. 74(17):7794-802.
4. Vidal VF. et al., 2001. Macrophage stimulation with Murabutide, an HIV-suppressive muramyl peptide derivative, selectively activates extracellular signal-regulated kinases 1 and 2, C/EBPbeta and STAT1: role of CD14 and Toll-like receptors 2 and 4. Eur J Immunol. 31(7):1962-71.
Specificity: NOD2 agonist
Working concentration: 1 - 100 ng/ml
CAS number: 74817-61-1
Solubility: 10 mg/ml in water
Molecular weight: 548.58
Synonym: N-Acetyl-muramyl-L- Alanyl-D-Glutamin-n-butyl-esterBack to the top
Murabutide is provided as a lyophilized powder.
- 5 mg Murabutide
- 2 ml sterile endotoxin-free water
Murabutide is shipped at room temperature.
Store at -20°C. Upon resuspension, aliquote murabutide and store at -20°C.
Product is stable 6 months at -20°C when properly stored.
Avoid repeated freeze-thaw cycles.Back to the top