M-TriLYS Unit size Cat. code Docs Qty Price
NOD2 Agonist - Synthetic muramyl tripeptide
1 mg

M-TriLYS (MurNAc-Ala-D-isoGln-Lys) is a muropeptide released by Lactobacillus salivarus, after digestion of its peptidoglycan (PGN).

Chemically synthesized M-TriLYS is sensed by NOD2 and induces the activation of NF-κB [1].

However, M-TriLYS has been shown to produce the anti-inflammatory cytokine IL-10 and protect mice from colitis, unlike M-TriLYSD-ASN [1].

The opposite effect of both muropeptides may be linked to a differential transport.


1. Macho Fernandez E. et al., 2011. Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide, Gut, 60: 1050 - 1059.

Back to the top


Specificity: NOD2 agonist

Working Concentration: 100 ng - 10 µg/ml

Endotoxin level:  EndoFit™ (<0.001 EU/µg)

Synonym: MurNAc-Ala-D-isoGln-Lys

Molecular weight: 620.65

Solubility: 1 mg/ml in water

Back to the top


  • 1 mg M-TriLYS provided lyophilized
  • 2 ml sterile endotoxin-free water

M-TriLYS is shipped at room temperature.

Store lyophilized product at -20˚C.

Lyophilized product is stable 6 months when properly stored.

Back to the top

Customer Service
& Technical Support

In order to prevent automated spam submissions, please answer the following question:
1 + 1 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Shopping cart is empty