M-TriLYS
| M-TriLYS | Unit size | Cat. code | Docs | Qty | Price |
|---|---|---|---|---|---|
NOD2 Agonist - Synthetic muramyl tripeptide |
1 mg |
tlrl-mtl |
NOD2 Agonist - Synthetic muramyl tripeptide
M-TriLYS (MurNAc-Ala-D-isoGln-Lys) is a muropeptide released by Lactobacillus salivarus, after digestion of its peptidoglycan (PGN).
Chemically synthesized M-TriLYS is sensed by NOD2 and induces the activation of NF-κB [1].
However, M-TriLYS has been shown to produce the anti-inflammatory cytokine IL-10 and protect mice from colitis, unlike M-TriLYSD-ASN [1].
The opposite effect of both muropeptides may be linked to a differential transport.
Reference:
1. Macho Fernandez E. et al., 2011. Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide, Gut, 60: 1050 - 1059.
Back to the topSpecifications
Specificity: NOD2 agonist
Working Concentration: 100 ng - 10 µg/ml
Endotoxin level: EndoFit™ (<0.001 EU/µg)
Synonym: MurNAc-Ala-D-isoGln-Lys
Molecular weight: 620.65
Solubility: 1 mg/ml in water
Back to the topContents
- 1 mg M-TriLYS provided lyophilized
- 2 ml sterile endotoxin-free water
M-TriLYS is shipped at room temperature.
Store lyophilized product at -20˚C.
Lyophilized product is stable 6 months when properly stored.