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#TLR7/8 Ligands

R848 (Resiquimod) - TLR7/8 Agonist

Imidazoquinoline compound - CAS #144875-48-9

NF-κB response of HEK-Blue™-derived cells to R848

NF-κB and IRF responses of THP1-Dual™-derived cells to R848

R848 chemical structure

#TLR7/8 Ligands

TL8-506 - TLR8 Agonist

Benzo-azepine analog - CAS #1268163-15-0

NF-κB response of HEK-Blue™-derived cells to TL8-506

NF-κB and IRF responses of THP1-Dual™-derived cells to TL8-506

ODN INH-18 - TLR9 Antagonist

Class B inhibitory ODN oligonucleotide

Dose-dependent inhibition of TLR9 activity by ODN INH-18.

ODN D-SL03 - TLR9 Agonist

CpG ODN, Class C (Multispecies)

Dose-dependent NF-κB response of ODN D-SL03 in HEK-Blue™ mTLR9 cells

ODN BW006 (ODN 684) - TLR9 Agonist

Stimulatory CpG ODN, Class B, Human/Mouse-preferred

Dose-dependent NF-κB response of ODN BW006 in HEK-Blue™ hTLR9 cells

ODN D-SL01 - TLR9 Agonist

CpG ODN, Class B (Multispecies)

Dose-dependent NF-κB response of ODN D-SL01 in HEK-Blue™ mTLR9 cells

#TLR7/8 Ligands

ssPolyU Naked - TLR8 Agonist

RNA homopolymer

NF-κB response of HEK-Blue™-derived cells to ssPolyU Naked

#TLR7/8 Ligands

ORN06/LyoVec™ - TLR7/8 Agonist

UUGU ssRNA polymer / LyoVec™ complexed

NF-κB response of HEK-Blue™-derived cells to ORN06/LyoVec™

ODN TTAGGG (A151) - TLR9 Antagonist

TLR9, AIM2, and cGAS antagonist

TLR9 signaling inhibition

Specific AIM2 inflammasome signaling inhibition

CDS signaling inhibition

ODN 4084-F - TLR9 Antagonist

Class B inhibitory ODN

Dose-dependent inhibition of TLR9 activity by ODN 4084-F

ODN 2088 control - TLR9 Ligand

Negative control for ODN 2088

Dose-dependent inhibition of TLR9 activity in HEK-Blue™ mTLR9 cells.

ODN 2088 - TLR9 Antagonist

Inhibitory ODN, preference towards mouse

Dose-dependent inhibition of TLR9 activity by ODN 2088

#TLR7/8 Ligands

Loxoribine - TLR7 Agonist

Guanosine analog - CAS #121288-39-9

NF-κB response of HEK-Blue™-derived cells to loxoribine

#TLR7/8 Ligands

Imiquimod (R837) - TLR7 Agonist

Imidazoquinoline compound - CAS #99011-78-6

NF-κB response of HEK-Blue™-derived cells to imiquimod

NF-κB and IRF responses of HEK-Dual™-derived cells to imiquimod

#TLR7/8 Ligands

Gardiquimod™ - TLR7 Agonist

Imidazoquinoline compound - CAS #1020412-43-4

NF-κB response of HEK-Blue™-derived cells to Gardiquimod™

NF-κB and IRF responses of THP1-Dual™-derived cells to Gardiquimod™

#TLR7/8 Ligands

CL264 - TLR7 Agonist

Adenine analog

NF-κB response of HEK-Blue™-derived cells to CL264

NF-κB and IRF responses of HEK-Dual™-derived cells to CL264

#TLR7/8 Ligands

CL097 - TLR7/TLR8 Agonist

Imidazoquinoline compound - CAS #1026249-18-2

NF-κB response of HEK-Blue™-derived cells to CL097

NF-κB and IRF responses of THP1-Dual™-derived cells to CL097

#TLR7/8 Ligands

CL075 (3M002) - TLR7/TLR8 Agonist

Thiazoquinoline compound - CAS #256922-53-9

NF-κB response of HEK-Blue™-derived cells to CL075

NF-κB and IRF responses of HEK-Dual™-derived cells to CL075

#TLR7/8 Ligands

ssRNA41/LyoVec™ - Negative Control

ssRNA40 negative control / LyoVec™ complexed

NF-κB response of HEK-Blue™ hTLR8 cells to ssRNA41/LyoVec™

#TLR7/8 Ligands

ssRNA40/LyoVec™ - TLR7/8 Agonist

HIV-1-derived ssRNA / LyoVec™ complexed

NF-κB response of HEK-Blue™-derived cells to ssRNA40/LyoVec™