ODN D-SL01
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Cat.code:
tlrl-dsl01
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ABOUT
Class B CpG oligonucleotide - Multispecies TLR9 ligand
ODN D-SL01 (double-stem loop ODN) is a synthetic oligonucleotide that contains unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs) that are recognized by TLR9 leading to strong immunostimulatory effects.
ODN D-SL01 is a type B CpG ODN and a TLR9 agonist in diverse vertebrate species, namely, humans, mice, rats, rabbits, pigs, and dogs.
ODN D-SL01 is composed of double stem loops, a phosphorothioate backbone, and two GACGTT motifs. D-SL01 has been shown to potently activate human B cells, NK cells, and mononuclear cells as well as PBMC/splenocytes obtained from diverse vertebrate species, namely, mice, rats, rabbits, dogs, and pigs [1].
ODN D-SL01 demonstrates anti-tumor activity in mice with established breast cancer [1].
Reference:
1. Yang L. et al., 2013. CpG oligodeoxynucleotides with double stem-loops show strong immunostimulatory activity. Int Immunopharmacol. 15(1):89-96.
All products are for research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
5’-tcg cga cgt tcg ccc gac gtt cgg ta-3’ (26 mer)
Note: Bases are phosphorothioate (nuclease resistant)
1-5 μM
0.2 µm filtration
TLR9 activity tested using HEK-Blue™ TLR9 cells, Absence of bacterial contamination confirmed using HEK-Blue™ TLR2 and TLR4 cells
TLR9 activity has been tested using HEK-Blue™ TLR9 cells.
The absence of bacterial contamination (e.g. lipoproteins and endotoxins) has been confirmed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells.
CONTENTS
Contents
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Product:ODN D-SL01
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Cat code:tlrl-dsl01
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Quantity:200 µg
1.5 ml endotoxin-free water
D-SL01 is sterile filtered prior to lyophilization.
Shipping & Storage
- Shipping method: Room temperature
- Upon receipt, store at -20°C.
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
DOCUMENTS
Documents
Technical Data Sheet
Validation Data Sheet
Safety Data Sheet
Certificate of analysis
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