Class B CpG oligonucleotide - Murine TLR9 ligand
CpG ODNs are synthetic oligonucleotides that contain unmethylated CpG dinucleotides in specific sequence contexts (CpG motifs). These CpG motifs are present at a 20-fold greater frequency in bacterial DNA than in mammalian DNA.
CpG ODNs are recognized by Toll-like receptor 9 (TLR9), which leads to strong immunostimulatory effects.
ODN 1826 is a class B CpG ODN specific for murine TLR9. B-class CpG ODNs contain a full phosphorothioate backbone with one or more CpG dinucleotides.
They strongly activate B cells but weakly stimulate IFN-α secretion in pDCs.