Class C CpG oligonucleotide - Human / Murine TLR9 ligand
CpG ODNs are synthetic oligonucleotides that contain unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs).
These CpG motifs are present at a 20-fold greater frequency in bacterial DNA compared to mammalian DNA. CpG ODNs are recognized by Toll-like receptor 9 (TLR9) leading to strong immunostimulatory effects.
ODN 2395 is a CpG ODN class C specific for human / mouse TLR9. C-class CpG ODNs contain a complete phosphorothioate backbone and a CpG-containing palindromic motif.
C-class CpG ODNs induce strong IFN-α production from pDC and B cell stimulation.