ODN BW006 (ODN 684)

ODN BW006 (ODN 684) Unit size Cat. code Docs Qty Price
Class B
200 µg

Class B CpG oligonucleotide - Human & mouse TLR9 ligand

ODN BW006 (also known as ODN 684) is a synthetic oligonucleotide that contains unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs), that are recognized by TLR9 leading to strong immunostimulatory effects.

ODN BW006 is a type B CpG ODN containing twice the optimal motif in human, GTCGTT [1 ]. ODN BW006 is capable of inducing the proliferation of human peripheral blood mononucleated cell (PBMCs) peripheral blood mononucleated cell (PBMCs) and mouse splenocytes, as vigorously as ODN 2006, a class B prototype ODN.

It was found to improve the rabies vaccine by inducing an earlier and more vigorous protective response1. ODN BW006 promotes strong Th1 response [2, 3].



1. Wang X. et al., 2008. A CpG oligodeoxynucleotide acts as a potent adjuvant for inactivated rabies virus vaccine.Vaccine. 26(15):1893-901.
2. Yan Y. et al., 2012. A CpG oligodeoxynucleotide potentiates the anti-tumor effect of HSP65-Her2 fusion protein against Her2 positive B16 melanoma in mice. Int Immunopharmacol. 12(2):402-7.
3. Zhang X. et al., 2011. Enhanced specific immune responses by CpG DNA in mice immunized with recombinant hepatitis B surface antigen and HB vaccine. Virol J. 8:78.

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Specificity: human and murine TLR9 agonist

Working concentration: 1-5 μM OR 1-50 µg/ml

ODN BW006 sequence
5’-tcg acg ttc gtc gtt cgt cgt tc-3’ (23 mer)
Note: Bases are phosphorothioate (nuclease resistant).

Quality control:

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  • 200 μg (27.24 nmol) of ODN BW006 provided lyophilized

Note: ODN BW006 is sterile filtered prior to lyophilization.

  • 1.5 ml endotoxin-free water

room temperature ODN BW006 is shipped at room temperature

store ODN BW006 should be stored at -20°C.

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