ODN BW006 (ODN 684) - TLR9 Agonist

Class B CpG oligonucleotide - Human & mouse TLR9 ligand

ODN BW006 (also known as ODN 684) is a synthetic oligonucleotide that contains unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs), that are recognized by TLR9 leading to strong immunostimulatory effects.

ODN BW006 is a type B CpG ODN containing twice the optimal motif in human, GTCGTT [1]. ODN BW006 induces the proliferation of human peripheral blood mononucleated cells (PBMCs), peripheral blood mononucleated cells, (PBMCs), and mouse splenocytes, as vigorously as ODN 2006, a class B prototype ODN.

It was found to improve the rabies vaccine by inducing an earlier and more vigorous protective response [1]. ODN BW006 promotes a strong Th1 response [2, 3].

References:

1. Wang X. et al., 2008. A CpG oligodeoxynucleotide acts as a potent adjuvant for inactivated rabies virus vaccine.Vaccine. 26(15):1893-901.
2. Yan Y. et al., 2012. A CpG oligodeoxynucleotide potentiates the anti-tumor effect of HSP65-Her2 fusion protein against Her2 positive B16 melanoma in mice. Int Immunopharmacol. 12(2):402-7.
3. Zhang X. et al., 2011. Enhanced specific immune responses by CpG DNA in mice immunized with recombinant hepatitis B surface antigen and HB vaccine. Virol J. 8:78.