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ODN INH-18

ODN INH-18 Unit size Cat. code Docs Qty Price
TLR9 antagonist - Class B inhibitory
200 µg
tlrl-inh18
+-
$173.00

TLR9 antagonist - Class B inhibitory ODN oligonucleotide

Toll-Like Receptor 9 (TLR9) detects unmethylated CpG dinucleotides in bacterial or viral DNA inducing strong immunostimulatory effects.

TLR9 activation can be mimicked by synthetic phosphorothioate-stabilized oligodeoxynucleotides (ODN) containing immune stimulatory “CpG motifs”.

Recent studies suggest the existence of DNA sequences that can neutralize the stimulatory effect of CpG ODNs.

ODN INH-18 is a linear and class R (‘restricted’) inhibitory ODN. It contains an inhibitory DNA motif consisting of two nucleotide triplets, a proximal CCT and a more distal GGG, spaced from each other by four nucleotides.

ODN INH-18 is a potent inhibitor of TLR9-induced B cells and macrophages [1]. ODN INH-18 strongly blocks TLR9 activation in both human and mouse TLR9-expressing cells.

 

1. Lenert P. et al., 2009. DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo. Arthritis Res Ther. 11(3):R79.

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Specifications

Specificity: TLR9 antagonist

ODN INH-18 sequence
5’-cct gga tgg gaa ctt acc gct gca-3’ (24 mer)
Note: Bases are phosphorothioate (nuclease resistant).

Quality control:

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Contents

  • 200 μg (25.9 nmol) of ODN INH-18 provided lyophilized
    Note: ODN INH-18 is sterile filtered prior to lyophilization.
  • 1.5 ml endotoxin-free water

room temperature ODN INH-18 is shipped at room temperature.

store Upon receipt, store at -20 °C.

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