Inhibitory oligodeoxynucleotides (iODNs) are DNA sequences capable of inhibiting the immunostimulatory effects induced by CpG ODNs. They function by modulating or blocking TLR9 activation. As such, they are valuable tools for studying the regulation of TLR9 signaling pathways and hold potential for therapeutic applications in cases of excessive inflammation or autoimmune disorders.
Invivogen offers a comprehensive range of TLR9-targeting inhibitory ODNs along with their corresponding control ODNs, allowing for rigorous comparative analyses. The activity of each of these TLR ligands has been thoroughly validated using HEK-Blue™ TLR9 Cells, ensuring their effectiveness in standardized experimental settings.