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#TLR7/8 Ligands

R848 (Resiquimod) - TLR7/8 Agonist

Imidazoquinoline compound - CAS #144875-48-9

NF-κB response of HEK-Blue™-derived cells to R848

NF-κB and IRF responses of THP1-Dual™-derived cells to R848

R848 chemical structure

#Multi-PRR Ligands

CL429 - TLR2 & NOD2 Bispecific Agonist

Pam2C-conjugated murabutide

Dose-dependent NF-κB response to CL429 in HEK-Blue™ hTLR2 and HEK-Blue™ hNOD2 cells

CL429 chemical structure

#TLR7/8 Ligands

TL8-506 - TLR8 Agonist

Benzo-azepine analog - CAS #1268163-15-0

NF-κB response of HEK-Blue™-derived cells to TL8-506

NF-κB and IRF responses of THP1-Dual™-derived cells to TL8-506

#Antibiotics Selection

HEK-Blue™ CLR Selection

Antibiotics for maintenance of HEK-Blue™ Dectin & Mincle cells

Recommended use of HEK-Blue™ CLR Selection

#Antibiotics Selection

Zeocin®

Selective antibiotic for the Sh ble gene

Zeocin® by InvivoGen

#Antibiotics Selection

Puromycin

Selective antibiotic for the pac gene

Puromycin by InvivoGen

Chemical structure of Puromycin

#Antibiotics Selection

Phleomycin

Selective antibiotic for the Sh ble gene

Phleomycin by InvivoGen

#Antibiotics Selection

Hygromycin B Gold

Selective antibiotic for the hph gene

Hygromycin B Gold™ by InvivoGen

Chemical structure of Hygromycin

#Antibiotics Selection

G418 (Geneticin)

Selective antibiotic for the neo gene

G418 (Geneticin) by InvivoGen

Chemical structure of G418 (Geneticin)

#Multi-PRR Ligands

Adilipoline™ (CL413) - TLR2 & TLR7 Bispecific Agonist

Chimeric molecule

Multi-PRR ligands TLR2 response

Multi-PRR ligands TLR7 response

#Multi-PRR Ligands

CL307 - TLR7 Agonist

Polycationic adenine analog

NF-κB response of HEK-Blue™-derived cells to CL307

NF-κB and IRF responses of THP1-Dual™-derived cells to CL307

#TLR7/8 Ligands

ssPolyU Naked - TLR8 Agonist

RNA homopolymer

NF-κB response of HEK-Blue™-derived cells to ssPolyU Naked

#TLR7/8 Ligands

ORN06/LyoVec™ - TLR7/8 Agonist

UUGU ssRNA polymer / LyoVec™ complexed

NF-κB response of HEK-Blue™-derived cells to ORN06/LyoVec™

#TLR7/8 Ligands

Loxoribine - TLR7 Agonist

Guanosine analog - CAS #121288-39-9

NF-κB response of HEK-Blue™-derived cells to loxoribine

#TLR7/8 Ligands

Imiquimod (R837) - TLR7 Agonist

Imidazoquinoline compound - CAS #99011-78-6

NF-κB response of HEK-Blue™-derived cells to imiquimod

NF-κB and IRF responses of HEK-Dual™-derived cells to imiquimod

#TLR7/8 Ligands

Gardiquimod™ - TLR7 Agonist

Imidazoquinoline compound - CAS #1020412-43-4

NF-κB response of HEK-Blue™-derived cells to Gardiquimod™

NF-κB and IRF responses of THP1-Dual™-derived cells to Gardiquimod™

#TLR7/8 Ligands

CL264 - TLR7 Agonist

Adenine analog

NF-κB response of HEK-Blue™-derived cells to CL264

NF-κB and IRF responses of HEK-Dual™-derived cells to CL264

#TLR7/8 Ligands

CL097 - TLR7/TLR8 Agonist

Imidazoquinoline compound - CAS #1026249-18-2

NF-κB response of HEK-Blue™-derived cells to CL097

NF-κB and IRF responses of THP1-Dual™-derived cells to CL097

#TLR7/8 Ligands

CL075 (3M002) - TLR7/TLR8 Agonist

Thiazoquinoline compound - CAS #256922-53-9

NF-κB response of HEK-Blue™-derived cells to CL075

NF-κB and IRF responses of HEK-Dual™-derived cells to CL075

#TLR7/8 Ligands

ssRNA41/LyoVec™ - Negative Control

ssRNA40 negative control / LyoVec™ complexed

NF-κB response of HEK-Blue™ hTLR8 cells to ssRNA41/LyoVec™