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#TLR7/8 Ligands

R848 (Resiquimod) - TLR7/8 Agonist

Imidazoquinoline compound - CAS #144875-48-9

NF-κB response of HEK-Blue™-derived cells to R848

NF-κB and IRF responses of THP1-Dual™-derived cells to R848

R848 chemical structure

TDB - Mincle Agonist

Synthetic analog of the cord factor

TDB dose-dependent activation of Mincle

NF-κB response to various Mincle agonists in HEK-Blue™ hMincle cells

#TLR7/8 Ligands

TL8-506 - TLR8 Agonist

Benzo-azepine analog - CAS #1268163-15-0

NF-κB response of HEK-Blue™-derived cells to TL8-506

NF-κB and IRF responses of THP1-Dual™-derived cells to TL8-506

HKCA - Dectin-1 Agonist

Heat-killed Candida albicans

HKCA dose-dependent activation of Dectin-1

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Curdlan - Dectin-1 Agonist

Beta-1,3-glucan from Alcaligenes faecalis

Curdlan dose-dependent activation of Dectin-1

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Partial structure of Curdlan

#Reporter Detection Reagents

HEK-Blue™ Detection - SEAP Detection Medium

Cell culture medium for real-time SEAP detection

HEK-Blue™ Detection by InvivoGen

Depleted Zymosan - Dectin-1 Agonist

Hot alkali–treated zymosan — Selective Dectin-1 agonist, depleted of TLR2 activity

Zymosan Depleted dose-dependent activation of Dectin-1

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Furfurman - Dectin-2 Agonist

Malassezia furfur cell wall preparation

Furfurman dose-dependent activation of Dectin-2

Laminarin - Dectin-1 Ligand

Soluble beta-glucan from Laminaria digitata - Dectin-1 Antagonist or Agonist

Laminarin dose-dependent activation of Dectin-1a

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Partial structure of Laminarin

#Reporter Detection Reagents

QUANTI-Luc™: Luciferase Detection Reagent

Luminescence detection kit for standard and HTS assays

Lucia luciferase detection for 10 min using QUANTI-Luc™ 4 Lucia/Gaussia

Lucia luciferase end-point detection using QUANTI-Luc™ 4 Lucia/Gaussia

Renilla luciferase detection for 20 min using QUANTI-Luc™ 4 Renilla

Renilla luciferase end-point detection using QUANTI-Luc™ 4 Renilla

#Reporter Detection Reagents

Recombinant Lucia® Luciferase Protein - Positive Control

Positive control for luciferase reporter assays

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#Reporter Detection Reagents

Recombinant SEAP Protein - Positive Control

Positive control for SEAP reporter assays

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#TLR7/8 Ligands

ssPolyU Naked - TLR8 Agonist

RNA homopolymer

NF-κB response of HEK-Blue™-derived cells to ssPolyU Naked

#TLR7/8 Ligands

ORN06/LyoVec™ - TLR7/8 Agonist

UUGU ssRNA polymer / LyoVec™ complexed

NF-κB response of HEK-Blue™-derived cells to ORN06/LyoVec™

#Reporter Detection Reagents

QUANTI-Blue™ - SEAP Detection Reagent

Alkaline phosphatase detection reagent

QUANTI-Blue™ Standard procedure

QUANTI-Blue™ High Throughput Screening (HTS) procedure

Zymosan - TLR2 & Dectin-1 Agonist

Cell wall preparation of S. cerevisiae

Zymosan dose-dependent activation of Dectin-1, TLR2, and TLR4

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

#TLR7/8 Ligands

Loxoribine - TLR7 Agonist

Guanosine analog - CAS #121288-39-9

NF-κB response of HEK-Blue™-derived cells to loxoribine

#TLR7/8 Ligands

Imiquimod (R837) - TLR7 Agonist

Imidazoquinoline compound - CAS #99011-78-6

NF-κB response of HEK-Blue™-derived cells to imiquimod

NF-κB and IRF responses of HEK-Dual™-derived cells to imiquimod

#TLR7/8 Ligands

Gardiquimod™ - TLR7 Agonist

Imidazoquinoline compound - CAS #1020412-43-4

NF-κB response of HEK-Blue™-derived cells to Gardiquimod™

NF-κB and IRF responses of THP1-Dual™-derived cells to Gardiquimod™

#TLR7/8 Ligands

CL264 - TLR7 Agonist

Adenine analog

NF-κB response of HEK-Blue™-derived cells to CL264

NF-κB and IRF responses of HEK-Dual™-derived cells to CL264