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#TLR7/8 Ligands

R848 (Resiquimod) - TLR7/8 Agonist

Imidazoquinoline compound - CAS #144875-48-9

NF-κB response of HEK-Blue™-derived cells to R848

NF-κB and IRF responses of THP1-Dual™-derived cells to R848

R848 chemical structure

#TLR7/8 Ligands

TL8-506 - TLR8 Agonist

Benzo-azepine analog - CAS #1268163-15-0

NF-κB response of HEK-Blue™-derived cells to TL8-506

NF-κB and IRF responses of THP1-Dual™-derived cells to TL8-506

#Reporter Detection Reagents

HEK-Blue™ Detection - SEAP Detection Medium

Cell culture medium for real-time SEAP detection

HEK-Blue™ Detection by InvivoGen

FLA-PA Ultrapure - TLR5 Agonist

Flagellin from P. aeruginosa

Inflammasome response using different Flagellins

#Reporter Detection Reagents

QUANTI-Luc™: Luciferase Detection Reagent

Luminescence detection kit for standard and HTS assays

Lucia luciferase detection for 10 min using QUANTI-Luc™ 4 Lucia/Gaussia

Lucia luciferase end-point detection using QUANTI-Luc™ 4 Lucia/Gaussia

Renilla luciferase detection for 20 min using QUANTI-Luc™ 4 Renilla

Renilla luciferase end-point detection using QUANTI-Luc™ 4 Renilla

#Reporter Detection Reagents

Recombinant Lucia® Luciferase Protein - Positive Control

Positive control for luciferase reporter assays

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#Reporter Detection Reagents

Recombinant SEAP Protein - Positive Control

Positive control for SEAP reporter assays

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#TLR7/8 Ligands

ssPolyU Naked - TLR8 Agonist

RNA homopolymer

NF-κB response of HEK-Blue™-derived cells to ssPolyU Naked

#TLR7/8 Ligands

ORN06/LyoVec™ - TLR7/8 Agonist

UUGU ssRNA polymer / LyoVec™ complexed

NF-κB response of HEK-Blue™-derived cells to ORN06/LyoVec™

Flagellin FliC - TLR5 Agonist

Recombinant flagellin from S. typhimurium

Rec FLA-ST dose-dependent activation of TLR5

FLA-ST - TLR5 Agonist

Standard and Ultrapure Flagellin from S. typhimurium

NF-κB - SEAP response

NF-κB (IL-8) - Lucia response

Inflammasome response using different Flagellins

FLA-BS - TLR5 Agonist

Standard and Ultrapure Flagellin from B. subtilis

Inflammasome response using different Flagellins

Response of HEK-Blue™ hTLR5 to TLR5 agonists

#Reporter Detection Reagents

QUANTI-Blue™ - SEAP Detection Reagent

Alkaline phosphatase detection reagent

QUANTI-Blue™ Standard procedure

QUANTI-Blue™ High Throughput Screening (HTS) procedure

#TLR7/8 Ligands

Loxoribine - TLR7 Agonist

Guanosine analog - CAS #121288-39-9

NF-κB response of HEK-Blue™-derived cells to loxoribine

#TLR7/8 Ligands

Imiquimod (R837) - TLR7 Agonist

Imidazoquinoline compound - CAS #99011-78-6

NF-κB response of HEK-Blue™-derived cells to imiquimod

NF-κB and IRF responses of HEK-Dual™-derived cells to imiquimod

#TLR7/8 Ligands

Gardiquimod™ - TLR7 Agonist

Imidazoquinoline compound - CAS #1020412-43-4

NF-κB response of HEK-Blue™-derived cells to Gardiquimod™

NF-κB and IRF responses of THP1-Dual™-derived cells to Gardiquimod™

#TLR7/8 Ligands

CL264 - TLR7 Agonist

Adenine analog

NF-κB response of HEK-Blue™-derived cells to CL264

NF-κB and IRF responses of HEK-Dual™-derived cells to CL264

#TLR7/8 Ligands

CL097 - TLR7/TLR8 Agonist

Imidazoquinoline compound - CAS #1026249-18-2

NF-κB response of HEK-Blue™-derived cells to CL097

NF-κB and IRF responses of THP1-Dual™-derived cells to CL097

#TLR7/8 Ligands

CL075 (3M002) - TLR7/TLR8 Agonist

Thiazoquinoline compound - CAS #256922-53-9

NF-κB response of HEK-Blue™-derived cells to CL075

NF-κB and IRF responses of HEK-Dual™-derived cells to CL075

#TLR7/8 Ligands

ssRNA41/LyoVec™ - Negative Control

ssRNA40 negative control / LyoVec™ complexed

NF-κB response of HEK-Blue™ hTLR8 cells to ssRNA41/LyoVec™