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VET-SAP® saponin adjuvant

Saponin vaccine adjuvant - CAS #8047-15-2

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Poly(I:C) (HMW) Cy5 - TLR3 agonist

Cy5-labeled poly(I:C) (HMW)

Validation of Cy5 fluorescent labeling by fluorescence microscopy

Validation of Cy5 fluorescent labeling by flow cytometry

Dose-dependent activation of TLR3 with Poly(I:C) Cy5

Poly(I:C) (HMW) Cy3 - TLR3 agonist

Cy3-labeled poly(I:C) (HMW)

Validation of Cy3 fluorescent labeling by flow cytometry

Validation of Cy3 fluorescent labeling by fluorescence microscopy

Dose-dependent activation of TLR3 with Poly(I:C) Cy3

#RLR and CDS Ligands

Poly(dA:dT) Rhodamine - RIG-I & CDS Agonist, AIM2 Inflammasome Inducer

Rhodamine labeled

Dose-dependent interferon regulatory factor (IRF) response to transfected Poly(dA:dT) Rhodamine in A549-Dual™ cells.

CL429 VacciGrade™ - TLR2 & NOD2-based Adjuvant

Pam2C-conjugated murabutide

Dose-dependent NF-κB response to CL429 in HEK-Blue™ hTLR2 and HEK-Blue™ hNOD2 cells

CL429 chemical structure

Poly(I:C) (LMW) Rhodamine - TLR3 Agonist

Rhodamine-labeled poly(I:C) (LMW)

Dose-dependent response to Poly(I:C) (LMW) Rhodamine in HEK-Blue™ hTLR3 cells

Pam3CSK4 VacciGrade™ - TLR2/TLR1-based Adjuvant

Synthetic triacylated lipopeptide | Th1 response

Evaluation of NF-κB activation with Pam3CSK4

Specificity of Pam3CSK4 activation

ODN 1585 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class A (Mouse) | Th1 response

Dose-dependent NF-κB response of ODN 1585 in HEK-Blue™ mTLR9 cells

NF-κB and IRF responses of ODN 1585 in THP1-Dual™ hTLR9 cells

CL413 VacciGrade™ - TLR2 & TLR7-based Adjuvant

Chimeric molecule | Th1/Th2 response

Tumor growth after CL413 or CL401 treatment

Survival curves for untreated as well as CL413- or CL401-treated mice

CL413 chemical structure

CL401 VacciGrade™ - TLR2 & TLR7-based Adjuvant

Pam2C-conjugated 8-hydroxyadenine| Th1/Th2 response

Tumor growth after CL413 or CL401 treatment

Survival curves for untreated as well as CL413- or CL401-treated mice

Anti-OVA mIgG levels at 15, 30 and 45 days after the initial immunization in different groups.

Anti-OVA total IgG, IgG1, and IgG2a levels 45 days after the initial immunization in different groups.

Quil-A® adjuvant

Saponin vaccine adjuvant

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Poly(I:C) (HMW) Biotin -TLR3 Agonist

Biotin-labeled poly(I:C) (HMW)

TLR3 activation by Poly(I:C) HMW Biotin

Binding of Poly(I:C) HMW Biotin to TLR3

#RLR and CDS Ligands

DMXAA - STING Ligand

Vadimezan, ASA404, murine STING ligand

NF-kB activation (SEAP reporter)

IRF activation (Lucia luciferase reporter)

Poly(I:C) (LMW) / LyoVec™ - RIG-I/MDA-5 Agonist

dsRNA - complexed with transfection reagent

Dose-dependent interferon regulatory factor (IRF) response to Poly(I:C) (LMW) / LyoVec™ in A549-Dual™ cells.

Poly(I:C) (HMW) / LyoVec™ - RIG-I/MDA5 Agonist

LyoVec™ complexed

Dose-dependent interferon regulatory factor (IRF) response to Poly(I:C) (HMW) / LyoVec™ in A549-Dual™ cells.

#RLR and CDS Ligands

Poly(dG:dC) - CDS Agonist

Naked or Complexed with Lyovec™

IRF response of RAW-Lucia™ ISG cells

#RLR and CDS Ligands

Poly(dA:dT) - RIG-I & CDS Agonist, AIM2 Inflammasome Inducer

Naked or Complexed with Lyovec™

Evaluation of inflammasome mediated-pyroptosis

#RLR and CDS Ligands

5'ppp-dsRNA Control - RIG-I Agonist Negative Control

Negative control for 5′ppp-dsRNA

RIG-I stimulation using 5’ppp-dsRNA and LyoVec™ in B16-Blue™ ISG cells

#RLR and CDS Ligands

5'ppp-dsRNA - RIG-I Agonist

5' triphosphate double stranded RNA - Naked or Complexed with Lyovec™

A549-Dual™ cellular response to 3p-hpRNA and 5`ppp-dsRNA

Cellular response to 3p-hpRNA and 5’ppp-dsRNA

LPS-EB VacciGrade™ - TLR4-based Adjuvant

Lipopolysaccharide from E. coli 0111:B4 | Th1 response

LPS-EB Vaccigrade™-dependent activation of TLR4