Poly(I:C) (LMW) Rhodamine
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Rhodamine-labeled TLR3 Agonist
Rhodamine-labeled poly(I:C) (LMW)
Poly(I:C) Rhodamine was chemically labeled by covalent coupling of a rhodamine probe containing a reactive alkylating group. This confers fluorescent properties to poly(I:C) (LMW) whilst retaining TLR3 recognition properties.
Polyinosinic-polycytidylic acid (poly(I:C)) is a synthetic analog of double stranded RNA (dsRNA), a molecular pattern associated with viral infection.
Both natural and synthetic dsRNAs are known to induce type I interferons (IFN) and other cytokines production.
Poly(I:C) is recognized by Toll-like receptor 3 (TLR3).
InvivoGen provides poly(I:C) with a high molecular weight (HMW) or a low molecular weight (LMW) that might activate the immune system differently.Back to the top
Specificity: TLR3 agonist
Working Concentration: 100 ng - 10 μg/ml
Spectral Properties of Rhodamine
- Excitation λ max: 546 nm
- Emission λ max: 576 nm
- 10 µg Poly(I:C) Rhodamine
- 2 ml sterile endotoxin-free water
Poly(I:C) Rhodamine is shipped at room temperature
Stored at -20°C.
Protect from light.
Lyophilized product is stable 6 months at -20°C. Upon resuspension, Poly(I:C) Rhodamine should be aliquoted and stored at -20°C.
Resuspended product is stable 3 months at -20°C.
Avoid repeated freeze-thaw cycles.Back to the top