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Poly(I:C) (LMW) Rhodamine

Poly(I:C) (LMW) Rhodamine Unit size Cat. code Docs Qty Price
Rhodamine-labeled TLR3 Agonist
10 µg
tlrl-piwr
+-
$105.00

Rhodamine-labeled poly(I:C) (LMW)

Poly(I:C) Rhodamine was chemically labeled by covalent coupling of a rhodamine probe containing a reactive alkylating group. This confers fluorescent properties to poly(I:C) (LMW) whilst retaining TLR3 recognition properties.

Polyinosinic-polycytidylic acid (poly(I:C)) is a synthetic analog of double stranded RNA (dsRNA), a molecular pattern associated with viral infection. Both natural and synthetic dsRNAs are known to induce type I interferons (IFN) and other cytokines production. Poly(I:C) is recognized by Toll-like receptor 3 (TLR3).
InvivoGen provides poly(I:C) with a high molecular weight (HMW) or a low molecular weight (LMW) that might activate the immune system differently.

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Specifications

Specificity: TLR3 agonist

Working Concentration: 100 ng - 10 μg/ml

Endotoxin level: EndoFit™ (<0.001 EU/μg)

Spectral Properties of Rhodamine
Excitation λ max: 546 nm
Emission λ max: 576 nm

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Contents

• 10 µg Poly(I:C) Rhodamine
• 2 ml sterile endotoxin-free water

Poly(I:C) Rhodamine is shipped at room temperature and should be stored at -20°C.

Protect from light. Lyophilized product is stable 6 months at -20°C. Upon resuspension, Poly(I:C) Rhodamine should be aliquoted and stored at -20°C.  Resuspended product is stable 3 months at -20°C. Avoid repeated freeze-thaw cycles.

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