Invivogen
Menu

DMXAA

DMXAA Unit size Cat. code Docs Qty Price
Murine STING ligand - Xanthenone Analog
5 mg
tlrl-dmx
+-
$144.00

Murine STING ligand

DMXAA (also known as Vadimezan or ASA404) was initially identified as a potent tumor vascular disrupting agent in mice.
The antitumor activity of DMXAA has been linked to its ability to induce a variety of cytokines and chemokines, including TNF-α, IP-10, IL-6 and RANTES [1].

DMXAA is also a potent inducer of IFN-β [1, 2]. Despite significant preclinical promise, DMXAA failed human clinical trials. Recent studies have demonstrated that DMXAA targets the STING pathway [3], and this in a mouse-specific manner; DMXAA has no effect on human STING [4,5]. A unique point mutation (S162A) located within the cyclic-dinucleotide-binding site of human STING has been identified that renders it sensitive to DMXAA.

 

1. Jassar AS. et al., 2005. Activation of tumor-associated macrophages by the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid induces an effective CD8+ T-cell-mediated antitumor immune response in murine models of lung cancer and mesothelioma. Cancer Res. 65(24):11752-61.
2. Roberts ZJ. et al., 2007. The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis. J Exp Med. 204(7):1559-69.
3. Prantner D. et al., 2012. 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential. J Biol Chem. 287(47):39776-88.
4. Conlon J. et al., 2013. Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid. J Immunol. 190(10):5216-25.
5. Kim S. et al., 2013. Anticancer Flavonoids Are Mouse-Selective STING Agonists. ACS Chem Biol. 8(7): 1396-1401.

Back to the top

Specifications

Description: Mouse STING ligand

Synonym: 5,6-dimethylxanthenone-4-acetic acid

CAS Number: 117570-53-3

Formula: C17H14O4

Molecular weight: 282.29

Purity: ≥ 97% by UHPLC

Solubility: 10 mg/ml in DMSO

Quality control:

  • Biological activity has been assessed by measuring induction of the interferon pathway in  cellular assays.
  • The absence of endotoxins and other bacterial contaminants has been  verified using HEK-Blue™ TLR4 and HEK-Blue™ TLR2 cells.
Back to the top

Contents

  • 5 mg of DMXAA

room temperature DMXAA is shipped at room temperature

store Stored at -20°C.

Product is sterile filtered prior to lyophilization.

Back to the top

Customer Service
& Technical Support

CAPTCHA
In order to prevent automated spam submissions, please answer the following question:
6 + 11 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Shopping cart is empty