diABZI (compound 3)

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Non-nucleotide-based STING agonist (trihydrochloride form)

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2 x 1 mg

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Activation of STING by diABZI
Activation of STING by diABZI

Potent non-nucleotide-based STING agonist

diABZI (CAS# 2138299-34-8), also known as diABZI (compound 3) trihydrochloride, is a novel non-nucleotide-based ligand that potently activates STING. Similar to the classical STING agonist, 2'3'-cGAMP, diABZI induces activation of type-I interferons and pro-inflammatory cytokines in vitro and in vivo [1].

diABZI is part of a family of small-molecule amidobenzimidazoles (ABZI) identified to compete with 2'3'-cGAMP [1]. diABZI takes advantage of the symmetrical nature of STING, with two ABZI molecules linked to create a single optimized dimeric ligand [1]. Structural studies have suggested that the activation of STING by classical CDNs requires a closed 'lid' conformation [2]. In contrast, diABZI activates STING while maintaining its open conformation [1]. Further research is needed to understand the implications of this difference.

diABZI represents a novel chemical class with different physicochemical properties (e.g. increased bioavailability) than the classical CDN class of STING agonists. Importantly, this provides more options for the clinical development of STING agonists for the treatment of various conditions (e.g. cancer and viral infection). It has been shown that treatment with diABZI significantly inhibits tumor growth in a mouse model of colorectal cancer [1]. Furthermore, recent papers have highlighted the potential of diABZI in the treatment of SARS-CoV-2 through the induction of an effective IFN response [3-4].


Key Features

  • Potent non-CDN STING agonist
  • Water-soluble (2 mg/ml)
  • Activation of the NF-κB- and IRF-dependent responses have been validated with InvivoGen’s THP1‑Dual™ Cells.


1. Ramanjulu, J.M. et al. 2018. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature 564, 439-443.
2. Shang, G. et al. 2019. Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. Nature 567(7748), 389–393.
3. Li, M. et al. 2021. Pharmacological activation of STING blocks SARS-CoV-2 infection. Science 6(59), eabi9007.
4. Zhu, Q. et al. 2021. Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system. Antiviral Research 187, 105015.


diABZI activates STING
diABZI activates STING

diABZI induces a dose-dependent response in THP1-Dual™ cells. The cells were incubated with increasing concentrations of diABZI or 2’3’-cGAMP. After overnight incubation (A) the NF-κB activity was assessed by measuring the SEAP activity in the supernatant using QUANTI-Blue™ Solution. Optical density (OD) at 630 nm is shown. (B) The IRF response was assessed by measuring the activity of Lucia luciferase in the supernatant using QUANTI‑Luc™. Fold change over non-induced cells is shown.

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Description: Non-CDN STING agonist

Synonym: diABZI (compound 3)

CAS number:  2138299-34-8

Formula: C42H51N13O7P2 •3HCl

Molecular weight: 959.3 g/mol

Solubility: 2 mg/ml in H2O

Working Concentration: 0.01 - 30 µM

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  • 2 x 1 mg diABZI (provided as a lyophilized powder)
  • 1.5 ml endotoxin-free water


room temperature diABZI is shipped at room temperature.

store Upon receipt, store at -20°C. 


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Chemical structure of diABZI (compound 3) trihydrochloride:


diABZI.HCl Chemical structure

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