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#Inflammasome Ligands

Cholesterol Crystals - NLRP3 Inflammasome Inducer

CAS number 57-88-5

Cholesterol Crystals structure invivogen

Microscopic analysis of Cholesterol Crystals

NLRP3 inflammasome activation by cholesterol crystals

Poly(I:C) (HMW) Cy5 - TLR3 agonist

Cy5-labeled poly(I:C) (HMW)

Validation of Cy5 fluorescent labeling by fluorescence microscopy

Validation of Cy5 fluorescent labeling by flow cytometry

Dose-dependent activation of TLR3 with Poly(I:C) Cy5

Poly(I:C) (HMW) Cy3 - TLR3 agonist

Cy3-labeled poly(I:C) (HMW)

Validation of Cy3 fluorescent labeling by flow cytometry

Validation of Cy3 fluorescent labeling by fluorescence microscopy

Dose-dependent activation of TLR3 with Poly(I:C) Cy3

Poly(I:C) (LMW) Rhodamine - TLR3 Agonist

Rhodamine-labeled poly(I:C) (LMW)

Dose-dependent response to Poly(I:C) (LMW) Rhodamine in HEK-Blue™ hTLR3 cells

#Inflammasome Ligands

Nano-SiO2 - NLRP3 Inflammasome Inducer

Silica dioxide nanoparticles

Evaluation of NLRP3 inflammasome activation with Nano-SiO2

TDB - Mincle Agonist

Synthetic analog of the cord factor

TDB dose-dependent activation of Mincle

NF-κB response to various Mincle agonists in HEK-Blue™ hMincle cells

Poly(I:C) (HMW) Biotin -TLR3 Agonist

Biotin-labeled poly(I:C) (HMW)

TLR3 activation by Poly(I:C) HMW Biotin

Binding of Poly(I:C) HMW Biotin to TLR3

HKCA - Dectin-1 Agonist

Heat-killed Candida albicans

HKCA dose-dependent activation of Dectin-1

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Curdlan - Dectin-1 Agonist

Beta-1,3-glucan from Alcaligenes faecalis

Curdlan dose-dependent activation of Dectin-1

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Partial structure of Curdlan

Poly(I:C) (LMW) / LyoVec™ - RIG-I/MDA-5 Agonist

dsRNA - complexed with transfection reagent

Dose-dependent interferon regulatory factor (IRF) response to Poly(I:C) (LMW) / LyoVec™ in A549-Dual™ cells.

Poly(I:C) (HMW) / LyoVec™ - RIG-I/MDA5 Agonist

LyoVec™ complexed

Dose-dependent interferon regulatory factor (IRF) response to Poly(I:C) (HMW) / LyoVec™ in A549-Dual™ cells.

#Inflammasome Ligands

CPPD Crystals - NLRP3 Inflammasome Inducer

Calcium Pyrophosphate Dihydrate crystals

Evaluation of inflammasome activation with CPPD crystals

#Inflammasome Ligands

MSU Crystals - NLRP3 Inflammasome Inducer

Monosodium Urate Crystals

Evaluation of inflammasome activation with MSU Crystals

#Inflammasome Ligands

Nigericin - NLRP3 Inflammasome Inducer

Nigericin sodium salt

Induction of IL-1β secretion by monocytes upon treatment with Nigericin

#Inflammasome Ligands

Hemozoin - NLRP3 Inflammasome Inducer

Synthetic heme crystal

Induction of IL-1β secretion by monocytes upon HZ treatment

#Inflammasome Ligands

ATP - NLRP3 Inflammasome Inducer

Adenosine 5'-triphosphate disodium salt

Induction of IL-1β secretion by monocytes upon HZ treatment

Depleted Zymosan - Dectin-1 Agonist

Hot alkali–treated zymosan — Selective Dectin-1 agonist, depleted of TLR2 activity

Zymosan Depleted dose-dependent activation of Dectin-1

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Furfurman - Dectin-2 Agonist

Malassezia furfur cell wall preparation

Furfurman dose-dependent activation of Dectin-2

Laminarin - Dectin-1 Ligand

Soluble beta-glucan from Laminaria digitata - Dectin-1 Antagonist or Agonist

Laminarin dose-dependent activation of Dectin-1a

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Partial structure of Laminarin

Poly(A:U) - TLR3 Agonist

Polyadenylic-polyuridylic acid