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RSL3 - GPX4 inhibitor & Ferroptosis inducer

Invitrofit™ Cell death modulator

RSL3 chemical structure

Ferroptosis induction by RSL3 (LDH readout)

Ferroptosis induction by RSL3 (HMGB1-Lucia readout)

Poly(I:C) (HMW) Cy5 - TLR3 agonist

Cy5-labeled poly(I:C) (HMW)

Validation of Cy5 fluorescent labeling by fluorescence microscopy

Validation of Cy5 fluorescent labeling by flow cytometry

Dose-dependent activation of TLR3 with Poly(I:C) Cy5

Poly(I:C) (HMW) Cy3 - TLR3 agonist

Cy3-labeled poly(I:C) (HMW)

Validation of Cy3 fluorescent labeling by flow cytometry

Validation of Cy3 fluorescent labeling by fluorescence microscopy

Dose-dependent activation of TLR3 with Poly(I:C) Cy3

Ferrostatin-1 - Ferroptosis inhibitor

InvitroFit™ Cell death modulator

Ferrostatin-1 chemical formula

Ferroptosis inhibition by Ferrostatin-1 (LDH readout)

Ferroptosis inhibition by Ferrostatin-1 (HMGB1-Lucia readout)

#TLR7/8 Ligands

R848 (Resiquimod) - TLR7/8 Agonist

Imidazoquinoline compound - CAS #144875-48-9

NF-κB response of HEK-Blue™-derived cells to R848

NF-κB and IRF responses of THP1-Dual™-derived cells to R848

R848 chemical structure

2’3’-cGAM(PS)2 (Rp/Sp) - STING Agonist

Bisphosphorothioate analog of 2'3'-cGAMP, (Rp/Sp) cyclic [G(2’,5’)psA(3’,5’)ps]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

2’3’-cGAM(PS)2 (Rp/Sp) structure

3'3'-cGAMP Fluorinated - STING Agonist

Difluoro 3'3'-cGAMP, cyclic [FdG(3’,5’)pFdA(3’,5’)p]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

3'3'-cGAMP Fluorinated structure

2'3'-cGAMP VacciGrade™ - STING-based Adjuvant

Mammalian (non-canonical) CDN - Cyclic [G(2’,5’)pA(3’,5’)p] | Th1/Th2 response

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

#RLR and CDS Ligands

Poly(dA:dT) Rhodamine - RIG-I & CDS Agonist, AIM2 Inflammasome Inducer

Rhodamine labeled

Dose-dependent interferon regulatory factor (IRF) response to transfected Poly(dA:dT) Rhodamine in A549-Dual™ cells.

CL429 VacciGrade™ - TLR2 & NOD2-based Adjuvant

Pam2C-conjugated murabutide

Dose-dependent NF-κB response to CL429 in HEK-Blue™ hTLR2 and HEK-Blue™ hNOD2 cells

CL429 chemical structure

#Multi-PRR Ligands

CL429 - TLR2 & NOD2 Bispecific Agonist

Pam2C-conjugated murabutide

Dose-dependent NF-κB response to CL429 in HEK-Blue™ hTLR2 and HEK-Blue™ hNOD2 cells

CL429 chemical structure

Human IL-33 Antibody

Mouse IgG1 (clone 19G8) - Hybridoma

Evaluation of hIL-33 inhibition

Human IL-28b (IFN-λ3) Antibody

Mouse IgG1 (clone 18F4) - Hybridoma

Dose-dependent neutralization of hIL-28b signaling

Human IL-28a (IFN-λ2) Antibody

Mouse IgG1 (clone 21C3) - Hybridoma

Anti-hIL-28a-IgG is a potent neutralization antibody

Human IL-1α Antibody

Mouse IgG1 (clone 7D4) - Hybridoma

Evaluation of hIL-1α inhibition

Human IFN-β Antibody

Mouse IgG2a (clone 10B10) - Hybridoma

Evaluation of hIFN-β inhibition

Poly(I:C) (LMW) Rhodamine - TLR3 Agonist

Rhodamine-labeled poly(I:C) (LMW)

Dose-dependent response to Poly(I:C) (LMW) Rhodamine in HEK-Blue™ hTLR3 cells

ODN 1585 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class A (Mouse) | Th1 response

Dose-dependent NF-κB response of ODN 1585 in HEK-Blue™ mTLR9 cells

NF-κB and IRF responses of ODN 1585 in THP1-Dual™ hTLR9 cells

Mouse IgG2b Isotype Control Antibody

E. coli β-Galactosidase antibody (clone T8H6) - Hybridoma

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Mouse IgG2a Isotype Control Antibody

E. coli β-Galactosidase antibody (clone T9C6) - Hybridoma

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