Human IL-28a (IFN-λ2) Antibody

Mouse IgG1 (clone 21C3) - Hybridoma

ABOUT

Neutralizing monoclonal antibody against human interleukin 28A

Anti-hIL-28a-IgG (clone 21C3) is a monoclonal antibody (mAb) for human interleukin 28A (hIL-28A). It is produced in hybridomas and purified by affinity chromatography. This antibody has been selected for its ability to efficiently neutralize the biological activity of hIL-28A. IL-28A (also known as interferon lambda 2) is a member of the type III interferon (IFN lambda) cytokine family that exhibits several common features with type I IFNs: antiviral activity and antitumor activity [1, 2]. 

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Key features:

  • A potent neutralizing mAb against hIL-28A
  • Provided azide-free
  • Each lot is functionally tested

 

References:

1. Donnelly RP. & Kotenko SV., 2010. Interferon-lambda: a new addition to an old family. J Interferon Cytokine Res. 30(8):555-64.
2. Li M. et al., 2009. Interferon-ls: the modulators of antivirus, antitumor, and immune responses. J. Leukoc. Biol., 86:23-32.

All products are for internal research use only, and not for human or veterinary use.

SPECIFICATIONS

Specifications

Target

IL-28A

Target species

Human

Crossreactivity

No cross-reactivity with mouse IL-28A or mouse IL-28B.

Isotype
mIgG1
Clone
21C3
Source
Hybridoma
Purification
Affinity chromatography
Formulation buffer

Sodium phosphate buffer with glycine, saccharose and stabilizing agents

Preservative
Azide-free
Appearance (form)
Lyophilized pellet
Appearance (color)
White
Tested applications

Neutralization assay

Quality control

Each lot is functionally tested and validated.

CONTENTS

Contents

  • Product: 
    Anti-hIL-28a-IgG
  • Cat code: 
    mabg-hil28a-3
  • Quantity: 
    3 x 100 µg

Shipping & Storage

  • Shipping method:  Room temperature
  • Storage:

    • -20°C

    Caution:

    • Avoid repeated freeze-thaw cycles

Details

The IFN-λ family is essential to the antiviral response at epithelial barriers[1,2]. In humans, this family comprises four distinct proteins called IFN-λ1 (interleukin-29, IL-29), IFN-λ2 (IL-28A), IFN-λ3 (IL-28B), and the poorly secreted IFN-λ4. In mice, two functional orthologs (IL-28A and IL-28B) have been described. IFN-λs are produced when a viral infection is sensed by pattern recognition receptors. IFN-λs bind to a heterodimeric receptor formed by the assembly of IFN lambda receptor 1 (IFNLR1) and IL-10 receptor beta (IL10Rβ). This leads to the recruitment of the Janus kinases, JAK1 and TyK2, and phosphorylation of STAT1 and STAT2, which then dimerize and interact with IFN regulatory factor 9 (IRF9), forming the ISGF3 complex. ISGF3 binds to IFN-stimulated response elements (ISRE) in the promoters of IFN-stimulated genes (ISG) to regulate their expression.

 

1. Lazear HM. et al., 2015. Interferon-λ: Immune Functions at Barrier Surfaces and Beyond. Immunity. 43(1):15-28.
2. Lee S. & Baldridge MT., 2017. Interferon- Lambda: A Potent Regulator of Intestinal Viral Infections. Front Immunol. 8:749.

DOCUMENTS

Documents

Anti-hIL-28a-IgG

Technical Data Sheet

Validation Data Sheet

Safety Data Sheet

Certificate of analysis

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