Invivogen
Menu

Anti-hIL-1α-IgG

Anti-hIL-1α-IgG Unit size Cat. code Docs Qty Price
Human IL-1α Neutralizing antibody - Monoclonal Human IgG1 (7D4)
3 x 100 µg
mabg-hil1a-3
+-
$267.00

Neutralizing monoclonal antibody against human interleukin-1 alpha

Anti-hIL-1α-IgG is a monoclonal mouse IgG1 antibody against human interleukin-1alpha (hIL-1α).

Interleukin-1 alpha (IL-1α) is a secreted pro-inflammatory cytokine produced primarily by activated macrophages [1]. IL-1α is synthesized as a pro-cytokine, which is enzymatically cleaved into the mature secreted form by calpain, a calcium-dependent protease [2]. In contrast to other cytokines, both the precursor and mature forms of IL-1α are biologically active. IL-1α plays a central role in the regulation of immune responses and inflammation. 

Anti-hIL-1α-IgG has been selected for its ability to efficiently neutralize the biological activity of hIL-1α.

This antibody is produced in hybridomas and purified by affinity chromatography.

 

References:

1. Sims J. & Smith D., 2010. The IL-1 family: regulators of immunity. Nat Rev Immunol. 10(2):89-102.
2. Dinarello C., 2009. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27:519–550.

Back to the top

Specifications

Applications: B/N (block/neutralize)

Target: natural and recombinant human interleukin-1 alpha (IL-1α)

Specificity: no cross-reactivity with human IL-1β, mouse IL-1α or mouse IL-1β

Clone: 7D4

Isotype: Mouse IgG1, kappa

Control: Mouse IgG1 Control

Immunogen: Human IL-1α protein expressed in Swiss mice following DNA immunization

Formulation: 0.2 µm filtered solution in sodium phosphate buffer with glycine, saccharose and stabilizing agents

Back to the top

Contents

  • 3x 100 µg purified anti-hIL-1α-IgG provided lyophilized

room temperature Product is shipped at room temperature.

store Store lyophilized antibody at -20°C.

Back to the top
Customer Service
& Technical Support
Shopping cart is empty