|Anti-hIL-1α-IgG||Unit size||Cat. code||Docs||Qty||Price|
Human IL-1α Neutralizing antibody - Monoclonal Human IgG1 (7D4)
3 x 100 µg
Neutralizing monoclonal antibody against human interleukin-1 alpha
Anti-hIL-1α-IgG is a monoclonal mouse IgG1 antibody against human interleukin-1alpha (hIL-1α).
Interleukin-1 alpha (IL-1α) is a secreted pro-inflammatory cytokine produced primarily by activated macrophages . IL-1α is synthesized as a pro-cytokine, which is enzymatically cleaved into the mature secreted form by calpain, a calcium-dependent protease . In contrast to other cytokines, both the precursor and mature forms of IL-1α are biologically active. IL-1α plays a central role in the regulation of immune responses and inflammation.
Anti-hIL-1α-IgG has been selected for its ability to efficiently neutralize the biological activity of hIL-1α.
This antibody is produced in hybridomas and purified by affinity chromatography.
1. Sims J. & Smith D., 2010. The IL-1 family: regulators of immunity. Nat Rev Immunol. 10(2):89-102.
2. Dinarello C., 2009. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27:519–550.
Applications: B/N (block/neutralize)
Target: natural and recombinant human interleukin-1 alpha (IL-1α)
Specificity: no cross-reactivity with human IL-1β, mouse IL-1α or mouse IL-1β
Isotype: Mouse IgG1, kappa
Control: Mouse IgG1 Control
Immunogen: Human IL-1α protein expressed in Swiss mice following DNA immunization
Formulation: 0.2 µm filtered solution in sodium phosphate buffer with glycine, saccharose and stabilizing agentsBack to the top
- 3x 100 µg purified anti-hIL-1α-IgG provided lyophilized
Product is shipped at room temperature.
Store lyophilized antibody at -20°C.Back to the top