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LPS-EB VacciGrade™ - TLR4-based Adjuvant

Lipopolysaccharide from E. coli 0111:B4 | Th1 response

LPS-EB Vaccigrade™-dependent activation of TLR4

TDB VacciGrade™ - Mincle-based Adjuvant

Synthetic analog of the cord factor | Th1 response

TDB dose-dependent activation of Mincle

ODN 2395 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class C (Human/mouse) | Th1 response

NF-κB response in HEK-Blue™-derived cells upon ODN 2395 stimulation

NF-κB and IRF response upon ODN 2395 stimulation

CFA

Complete Freund’s Adjuvant | Th1 response

Anti-Ova mIgG levels at 15 and 30 days after the initial immunization with CFA

Recombinant human IL-6 protein - Bioactive cytokine

Recombinant cytokine, source: E. coli

Detection by SDS-PAGE

Dose-response in HEK-Blue™ IL-6 cells to recombinant IL-6 cytokine

Neutralization of cellular response to IL-6 using tocilizumab biosimilar

Recombinant human IL-4 protein (E. coli) - Bioactive cytokine

Recombinant cytokine, source: E. coli

Detection by SDS-PAGE

Dose-response in HEK-Blue™ IL-4/IL-13 cells to recombinant IL-4 cytokine

Neutralization of cellular response to IL-4 using Dupilumab biosimilar

Recombinant human IL-1β protein (E. coli) - Bioactive cytokine

Recombinant cytokine, source: E. coli

Dose-response in HEK-Blue™ IL-1β cells to recombinant IL-1β cytokines

Detection of E. coli-derived IL-1β by SDS-PAGE

Recombinant human IFN-γ protein - Bioactive cytokine

Recombinant cytokine, source: E. coli

Detection by SDS-PAGE

Dose-response in HEK-Blue™ IFN-γ cells to human IFN-γ

Recombinant human CD40L protein (E. coli) - Bioactive cytokine

Recombinant cytokine, source: E. coli

Detection by SDS-PAGE

Dose-response in HEK-Blue™ CD40 cells to recombinant hCD40L cytokine

OVA peptides

Two OVA peptide standards for ELISPOT

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OVA protein

OVA (ovalbumin) for in vitro use

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EndoFit™ OVA protein

OVA (ovalbumin) for in vivo use

Anti-Ova mIgG levels at 15, 30 and 45 days after the initial immunization with IFA

R848 VacciGrade™ - TLR7/8-based Adjuvant

Imidazoquinoline compound | Th1 response

NF-κB response of HEK-Blue™-derived cells to R848

NF-κB and IRF responses of THP1-Dual™-derived cells to R848

Poly(I:C) (HMW) VacciGrade™ - TLR3-based Adjuvant

Polyinosine-polycytidylic acid | Th1 response

Dose-dependent activation of TLR3

ODN 2006 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class B (Human) | Th1 response

Species-driven TLR9 differential responses

NF-κB response induced by ODN 2006

IRF response induced by ODN 2006

ODN 2216 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class A (Human) | Th1 response

Dose-dependent NF-κB response of ODN 2216 in HEK-Blue™ hTLR9 cells

Dose-dependent NF-κB and IRF responses in THP1-Dual™ hTLR9 cells

ODN 1826 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class B (Mouse) | Th1 response

NF-κB response of ODN 1826 in HEK-Blue™-derived cells

NF-κB and IRF responses of ODN 1826 in THP1-Dual™ hTLR9 cells

MPLA-SM VacciGrade™- TLR4-based Adjuvant

Monophosphoryl lipid A | Th1 response

Activation of mouse and human TLR4

Absence of TLR2-activating contaminants

Imiquimod VacciGrade™ (R837) - TLR7-based Adjuvant

Imidazoquinoline compound | Th1 response

NF-κB response of HEK-Blue™-derived cells to imiquimod

NF-κB and IRF responses of HEK-Dual™-derived cells to imiquimod

Flagellin FliC VacciGrade™ - TLR5-based Adjuvant

Recombinant flagellin from S. typhimurium | Th1/Th2 response

Rec FLA-ST dose-dependent activation of TLR5