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#Custom Services

Custom Cell Line Development Service

Our custom cell line development service is designed to support your specific experimental goals

Overexpression confirmation

Biological activity validation

Stability testing

#Custom Services

PRR Compound Screening and Profiling

Our screening service can assess activation or inhibition of innate immune pathways by pattern recognition receptors

Level 1 Compound Profiling Example Figure

Level 2 Compound Dose Response Example Figure

#Custom Services

Custom Cloning Service

Specialized plasmids designed to meet your unique experimental needs

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#Custom Services

Cytokines Compound Screening

Our profiling service enables the detection of bioactive effects in your samples.

Dose-response of HEK-Blue™-derived cells to compound of interest

Dose-dependent inhibition of HEK-Blue™-derived cell response using the compound of interest

Poly(I:C) (HMW) Cy5 - TLR3 agonist

Cy5-labeled poly(I:C) (HMW)

Validation of Cy5 fluorescent labeling by fluorescence microscopy

Validation of Cy5 fluorescent labeling by flow cytometry

Dose-dependent activation of TLR3 with Poly(I:C) Cy5

Poly(I:C) (HMW) Cy3 - TLR3 agonist

Cy3-labeled poly(I:C) (HMW)

Validation of Cy3 fluorescent labeling by flow cytometry

Validation of Cy3 fluorescent labeling by fluorescence microscopy

Dose-dependent activation of TLR3 with Poly(I:C) Cy3

Poly(I:C) (LMW) Rhodamine - TLR3 Agonist

Rhodamine-labeled poly(I:C) (LMW)

Dose-dependent response to Poly(I:C) (LMW) Rhodamine in HEK-Blue™ hTLR3 cells

M-TriLYS - NOD2 Agonist

Synthetic muramyl tripeptide

M-TriLYS dose-dependent activation of NOD2

Poly(I:C) (HMW) Biotin -TLR3 Agonist

Biotin-labeled poly(I:C) (HMW)

TLR3 activation by Poly(I:C) HMW Biotin

Binding of Poly(I:C) HMW Biotin to TLR3

Poly(I:C) (LMW) / LyoVec™ - RIG-I/MDA-5 Agonist

dsRNA - complexed with transfection reagent

Dose-dependent interferon regulatory factor (IRF) response to Poly(I:C) (LMW) / LyoVec™ in A549-Dual™ cells.

Poly(I:C) (HMW) / LyoVec™ - RIG-I/MDA5 Agonist

LyoVec™ complexed

Dose-dependent interferon regulatory factor (IRF) response to Poly(I:C) (HMW) / LyoVec™ in A549-Dual™ cells.

PGN-SAndi ultrapure peptidoglycan - NOD2 Agonist

Insoluble peptidoglycan from S. aureus

Dose-dependent NF-κB response to PGN-SAndi Ultrapure in HEK-Blue™ hNOD2 cells

PGN-ECndss ultrapure peptidoglycan - NOD1/NOD2 Agonist

Soluble sonicated peptidoglycan from E. coli K12

Dose-dependent NF-κB response of PGN-ECndss Ultrapure in HEK-Blue™ hNOD1 and HEK-Blue™ hNOD2 cells

PGN-ECndi Ultrapure Peptidoglycan - NOD2 Agonist

Insoluble peptidoglycan from E. coli K12

Dose-dependent NF-κB response to PGN-ECndi Ultrapure in HEK-Blue™ hNOD1 and HEK-Blue™ hNOD2 cells

M-TriDAP - NOD1/NOD2 Agonist

MurNAc-L-Ala-gamma-D-Glu-mDAP - PGN-like molecule

NF-κB responses of HEK-Blue™ hNOD1 cells to various PRR agonists and cytokines

NF-kB response of HEK-Blue™ hNOD2 cells to various PRR agonists and cytokines

Murabutide - NOD2 Agonist

Synthetic derivative of muramyldipeptide

Murabutide dose-dependent activation of NOD2

N-Glycolyl-MDP - NOD2 Agonist

N-glycolylated muramyldipeptide

N-Glycolyl-MDP dose-dependent activation of NOD2

L18-MDP - NOD2 Agonist

Muramyldipeptide with a C18 fatty acid chain

L18-MDP dose-dependent activation of NOD2

MDP Control - NOD2 Agonist Negative Control

Negative control for MDP - Muramyldipeptide (L-L isomer, inactive)

Dose-dependent NF-κB response in HEK-Blue™ hNOD2 cells

MDP - NOD2 Agonist

Muramyl dipeptide (L-D isomer)

MDP dose-dependent activation of NOD2