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#Inflammasome Ligands

Cholesterol Crystals - NLRP3 Inflammasome Inducer

CAS number 57-88-5

Cholesterol Crystals structure invivogen

Microscopic analysis of Cholesterol Crystals

NLRP3 inflammasome activation by cholesterol crystals

2’3’-cGAM(PS)2 (Rp/Sp) - STING Agonist

Bisphosphorothioate analog of 2'3'-cGAMP, (Rp/Sp) cyclic [G(2’,5’)psA(3’,5’)ps]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

2’3’-cGAM(PS)2 (Rp/Sp) structure

3'3'-cGAMP Fluorinated - STING Agonist

Difluoro 3'3'-cGAMP, cyclic [FdG(3’,5’)pFdA(3’,5’)p]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

3'3'-cGAMP Fluorinated structure

2'3'-cGAMP VacciGrade™ - STING-based Adjuvant

Mammalian (non-canonical) CDN - Cyclic [G(2’,5’)pA(3’,5’)p] | Th1/Th2 response

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

2'3'-cGAMP - STING Agonist

Mammalian (non-canonical) CDN, cyclic [G(2’,5’)pA(3’,5’)p]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

#Inflammasome Ligands

Nano-SiO2 - NLRP3 Inflammasome Inducer

Silica dioxide nanoparticles

Evaluation of NLRP3 inflammasome activation with Nano-SiO2

c-di-AMP VacciGrade™ - STING-based Adjuvant

Cyclic diadenylate monophosphate | Th1/Th2 response

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

#TLR-NOD (Kits) Ligands

Mouse TLR9 Agonist Kit

Set of known agonists for mouse TLR9

Dose-dependent NF-κB response of ODN 1585 in HEK-Blue™ mTLR9 cells

NF-κB response of ODN 1826 in HEK-Blue™-derived cells

NF-κB response in HEK-Blue™-derived cells upon ODN 2395 stimulation

#TLR-NOD (Kits) Ligands

Human TLR9 Agonist Kit

Set of known agonists for human TLR9

Dose-dependent NF-κB response of ODN 2216 in HEK-Blue™ hTLR9 cells

Dose-dependent NF-κB response in HEK-Blue™ hTLR9 cells.

NF-κB responses in HEK-Blue™ mTLR9 cells

#TLR-NOD (Kits) Ligands

Human TLR3/7/8/9 Agonist kit

14 ligands for human TLR3, TLR7, TLR8 and TLR9

Response of HEK-Blue™-derived cells to TLR3 agonists

NF-κB response of HEK-Blue™-derived cells to R848

NF-κB response of HEK-Blue™-derived cells to ssRNA40/LyoVec™

Dose-dependent NF-κB response in HEK-Blue™ hTLR9 cells.

#TLR-NOD (Kits) Ligands

Mouse TLR1-9 Agonist kit

9 ligands for murine TLR1 to TLR9

Evaluation of NF-κB activation with Pam3CSK4

Dose-dependent activation of TLR3

LPS-EK Standard-dependent activation of TLR2 and TLR4

NF-κB response of ODN 1826 in HEK-Blue™-derived cells

#TLR-NOD (Kits) Ligands

Human TLR1-9 Agonist kit

10 ligands for human TLR1 to TLR9

Dose-dependent activation of TLR2 by FSL-1

Dose-dependent activation of TLR3

LPS-EK Standard-dependent activation of TLR2 and TLR4

NF-κB response induced by ODN 2006

#Inflammasome Ligands

CPPD Crystals - NLRP3 Inflammasome Inducer

Calcium Pyrophosphate Dihydrate crystals

Evaluation of inflammasome activation with CPPD crystals

#Inflammasome Ligands

MSU Crystals - NLRP3 Inflammasome Inducer

Monosodium Urate Crystals

Evaluation of inflammasome activation with MSU Crystals

#Inflammasome Ligands

Nigericin - NLRP3 Inflammasome Inducer

Nigericin sodium salt

Induction of IL-1β secretion by monocytes upon treatment with Nigericin

#Inflammasome Ligands

Hemozoin - NLRP3 Inflammasome Inducer

Synthetic heme crystal

Induction of IL-1β secretion by monocytes upon HZ treatment

#Inflammasome Ligands

ATP - NLRP3 Inflammasome Inducer

Adenosine 5'-triphosphate disodium salt

Induction of IL-1β secretion by monocytes upon HZ treatment

c-di-GMP VacciGrade™ - STING-based Adjuvant

Cyclic diguanylate monophosphate | Th1/Th2 response

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

3'3'-cGAMP - STING Agonist

Bacterial (canonical) CDN, cyclic [G(3’,5’)pA(3’,5’)p]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

ADU-S100 - STING Agonist

Bisphosphorothioate analog of 2'3'-c-di-AMP, (Rp;Rp) cyclic [A(2’,5’)psA(3’,5’)ps]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)