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Poly(I:C) (HMW) Cy5 - TLR3 agonist

Cy5-labeled poly(I:C) (HMW)

Validation of Cy5 fluorescent labeling by fluorescence microscopy

Validation of Cy5 fluorescent labeling by flow cytometry

Dose-dependent activation of TLR3 with Poly(I:C) Cy5

Poly(I:C) (HMW) Cy3 - TLR3 agonist

Cy3-labeled poly(I:C) (HMW)

Validation of Cy3 fluorescent labeling by flow cytometry

Validation of Cy3 fluorescent labeling by fluorescence microscopy

Dose-dependent activation of TLR3 with Poly(I:C) Cy3

#TLR7/8 Ligands

R848 (Resiquimod) - TLR7/8 Agonist

Imidazoquinoline compound - CAS #144875-48-9

NF-κB response of HEK-Blue™-derived cells to R848

NF-κB and IRF responses of THP1-Dual™-derived cells to R848

R848 chemical structure

Poly(I:C) (LMW) Rhodamine - TLR3 Agonist

Rhodamine-labeled poly(I:C) (LMW)

Dose-dependent response to Poly(I:C) (LMW) Rhodamine in HEK-Blue™ hTLR3 cells

#TLR7/8 Ligands

TL8-506 - TLR8 Agonist

Benzo-azepine analog - CAS #1268163-15-0

NF-κB response of HEK-Blue™-derived cells to TL8-506

NF-κB and IRF responses of THP1-Dual™-derived cells to TL8-506

Poly(I:C) (HMW) Biotin -TLR3 Agonist

Biotin-labeled poly(I:C) (HMW)

TLR3 activation by Poly(I:C) HMW Biotin

Binding of Poly(I:C) HMW Biotin to TLR3

Poly(I:C) (LMW) / LyoVec™ - RIG-I/MDA-5 Agonist

dsRNA - complexed with transfection reagent

Dose-dependent interferon regulatory factor (IRF) response to Poly(I:C) (LMW) / LyoVec™ in A549-Dual™ cells.

Poly(I:C) (HMW) / LyoVec™ - RIG-I/MDA5 Agonist

LyoVec™ complexed

Dose-dependent interferon regulatory factor (IRF) response to Poly(I:C) (HMW) / LyoVec™ in A549-Dual™ cells.

#TLR7/8 Ligands

ssPolyU Naked - TLR8 Agonist

RNA homopolymer

NF-κB response of HEK-Blue™-derived cells to ssPolyU Naked

Poly(A:U) - TLR3 Agonist

Polyadenylic-polyuridylic acid

Poly(I:C) (HMW) Fluorescein - TLR3 Agonist

Fluorescent-labeled poly(I:C) (HMW)

Dose-dependent response to Poly(I:C) (HMW) Fluorescein in HEK-Blue™ hTLR3 cells

Poly(I:C) (HMW) Rhodamine - TLR3 Agonist

Rhodamine-labeled poly(I:C) (HMW)

Dose-dependent response to Poly(I:C) (HMW) Rhodamine in HEK-Blue™ hTLR3 cells

Poly(I:C) LMW - TLR3 Agonist

Low molecular weight polyinosine-polycytidylic acid

Dose-dependent activation of TLR3

Poly(I:C) HMW - TLR3 Agonist

High molecular weight polyinosine-polycytidylic acid

Dose-dependent activation of TLR3

#TLR7/8 Ligands

CL097 - TLR7/TLR8 Agonist

Imidazoquinoline compound - CAS #1026249-18-2

NF-κB response of HEK-Blue™-derived cells to CL097

NF-κB and IRF responses of THP1-Dual™-derived cells to CL097

#TLR7/8 Ligands

CL075 (3M002) - TLR7/TLR8 Agonist

Thiazoquinoline compound - CAS #256922-53-9

NF-κB response of HEK-Blue™-derived cells to CL075

NF-κB and IRF responses of HEK-Dual™-derived cells to CL075

NexaVant™ - TLR3 Agonist

Synthetic double stranded RNA

Molecular weight of NexaVant™ (agarose gel)

Comparison of TLR3 ligands (NF-κB and IRF responses)

NF-κB and IRF dose-responses of HEK-Dual™ hTLR3 cells

#TLR7/8 Ligands

TL7-887 (maleimide) and TL7-975 (azido) - Conjugatable TLR7 Ligands

Conjugatable adenine analogs

Biological activity of TL7-887

Biological activity of Anti-TROP2/TL7-887 in co-cultures

Biological activity of TL7-975

Biological activity of TL7-975 conjugated to Anti-HER2-hIgG1