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#TLR7/8 Ligands

ssPolyU Naked - TLR8 Agonist

RNA homopolymer

NF-κB response of HEK-Blue™-derived cells to ssPolyU Naked

#TLR7/8 Ligands

ORN06/LyoVec™ - TLR7/8 Agonist

UUGU ssRNA polymer / LyoVec™ complexed

NF-κB response of HEK-Blue™-derived cells to ORN06/LyoVec™

#TLR7/8 Ligands

Loxoribine - TLR7 Agonist

Guanosine analog - CAS #121288-39-9

NF-κB response of HEK-Blue™-derived cells to loxoribine

#TLR7/8 Ligands

Imiquimod (R837) - TLR7 Agonist

Imidazoquinoline compound - CAS #99011-78-6

NF-κB response of HEK-Blue™-derived cells to imiquimod

NF-κB and IRF responses of HEK-Dual™-derived cells to imiquimod

#TLR7/8 Ligands

Gardiquimod™ - TLR7 Agonist

Imidazoquinoline compound - CAS #1020412-43-4

NF-κB response of HEK-Blue™-derived cells to Gardiquimod™

NF-κB and IRF responses of THP1-Dual™-derived cells to Gardiquimod™

#TLR7/8 Ligands

CL264 - TLR7 Agonist

Adenine analog

NF-κB response of HEK-Blue™-derived cells to CL264

NF-κB and IRF responses of HEK-Dual™-derived cells to CL264

#TLR7/8 Ligands

CL097 - TLR7/TLR8 Agonist

Imidazoquinoline compound - CAS #1026249-18-2

NF-κB response of HEK-Blue™-derived cells to CL097

NF-κB and IRF responses of THP1-Dual™-derived cells to CL097

#TLR7/8 Ligands

CL075 (3M002) - TLR7/TLR8 Agonist

Thiazoquinoline compound - CAS #256922-53-9

NF-κB response of HEK-Blue™-derived cells to CL075

NF-κB and IRF responses of HEK-Dual™-derived cells to CL075

#TLR7/8 Ligands

ssRNA41/LyoVec™ - Negative Control

ssRNA40 negative control / LyoVec™ complexed

NF-κB response of HEK-Blue™ hTLR8 cells to ssRNA41/LyoVec™

#TLR7/8 Ligands

ssRNA40/LyoVec™ - TLR7/8 Agonist

HIV-1-derived ssRNA / LyoVec™ complexed

NF-κB response of HEK-Blue™-derived cells to ssRNA40/LyoVec™

#TLR7/8 Ligands

ssPolyU/LyoVec™ - TLR8 Agonist

RNA homopolymer / LyoVec™ complexed

NF-κB response of HEK-Blue™-derived cells to ssPolyU/LyoVec™

Recombinant human IFN-α10 protein - Bioactive cytokine

Recombinant cytokine, source: CHO cells

Human IFN-α10 SDS-PAGE analysis

Dose-response of HEK-Blue™ IFN-α/β cells to recombinant human IFN-α10

Fc-hDectin-1a

Soluble human Dectin-1 receptor

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Recombinant human & mouse IL-16 proteins - Bioactive cytokines

Recombinant cytokine, source: HEK cells

Detection by SDS-PAGE and WES

Detection of murine IL-16 by ELISA

Detection of human IL-16 by ELISA

Absence of bacterial contamination in recombinant mIL-16

Absence of bacterial contamination in recombinant hIL-16

Recombinant human IL-2 protein - Bioactive cytokine

Recombinant cytokine, source: CHO cells

Detection of IL-2 by SDS-PAGE

Dose-response in HEK-Blue™ IL-2 cells

Recombinant Human CD27-Fc Fusion Protein

Soluble human CD27 fused to an IgG1 Fc domain

hCD27-Fc analysis by SDS-PAGE

Cell surface staining using hCD27-Fc

ELISA detection of hCD27-Fc

Recombinant Human Fc-hCD70 Fusion Protein

Soluble human CD70 (CD27L) fused to an IgG1 Fc domain

Fc-hCD70 analysis by SDS-PAGE

Cell surface staining using Fc-hCD70

ELISA detection of Fc-hCD70

Activation of Jurkat-Lucia™ hCD27 cells using a CD27 agonist

Recombinant Human Fc-h4-1BBL Fusion Protein

Soluble human 4-1BBL (CD137L) fused to an IgG1 Fc domain

Fc-h4-1BBL analysis by SDS-PAGE

Cell surface staining using Fc-h4-1BBL

ELISA detection of Fc-h4-1BBL

Activation of Jurkat-Lucia™ h4-1BB cells

Recombinant Human CTLA-4-Fc Fusion Protein

Soluble human CTLA-4 (CD152) fused to an IgG1 Fc domain

hCTLA4-Fc analysis by SDS-PAGE

Cell surface staining using hCTLA4-Fc

ELISA detection of hCTLA4-Fc

Activation blockade of Jurkat-Lucia™ TCR-hPD-1 cells

Recombinant Human PD1-Fc Fusion Protein

Soluble human PD-1 (CD279) fused to an IgG1 Fc domain

hPD1-Fc analysis by SDS-PAGE

Cell surface staining using hPD1-Fc

ELISA detection of hPD1-Fc