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#Inflammasome Ligands

Cholesterol Crystals - NLRP3 Inflammasome Inducer

CAS number 57-88-5

Cholesterol Crystals structure invivogen

Microscopic analysis of Cholesterol Crystals

NLRP3 inflammasome activation by cholesterol crystals

#Inflammasome Ligands

Nano-SiO2 - NLRP3 Inflammasome Inducer

Silica dioxide nanoparticles

Evaluation of NLRP3 inflammasome activation with Nano-SiO2

#TLR-NOD (Kits) Ligands

Mouse TLR9 Agonist Kit

Set of known agonists for mouse TLR9

Dose-dependent NF-κB response of ODN 1585 in HEK-Blue™ mTLR9 cells

NF-κB response of ODN 1826 in HEK-Blue™-derived cells

NF-κB response in HEK-Blue™-derived cells upon ODN 2395 stimulation

#TLR-NOD (Kits) Ligands

Human TLR9 Agonist Kit

Set of known agonists for human TLR9

Dose-dependent NF-κB response of ODN 2216 in HEK-Blue™ hTLR9 cells

Dose-dependent NF-κB response in HEK-Blue™ hTLR9 cells.

NF-κB responses in HEK-Blue™ mTLR9 cells

#TLR-NOD (Kits) Ligands

Human TLR3/7/8/9 Agonist kit

14 ligands for human TLR3, TLR7, TLR8 and TLR9

Response of HEK-Blue™-derived cells to TLR3 agonists

NF-κB response of HEK-Blue™-derived cells to R848

NF-κB response of HEK-Blue™-derived cells to ssRNA40/LyoVec™

Dose-dependent NF-κB response in HEK-Blue™ hTLR9 cells.

#TLR-NOD (Kits) Ligands

Mouse TLR1-9 Agonist kit

9 ligands for murine TLR1 to TLR9

Evaluation of NF-κB activation with Pam3CSK4

Dose-dependent activation of TLR3

LPS-EK Standard-dependent activation of TLR2 and TLR4

NF-κB response of ODN 1826 in HEK-Blue™-derived cells

#TLR-NOD (Kits) Ligands

Human TLR1-9 Agonist kit

10 ligands for human TLR1 to TLR9

Dose-dependent activation of TLR2 by FSL-1

Dose-dependent activation of TLR3

LPS-EK Standard-dependent activation of TLR2 and TLR4

NF-κB response induced by ODN 2006

#Inflammasome Ligands

CPPD Crystals - NLRP3 Inflammasome Inducer

Calcium Pyrophosphate Dihydrate crystals

Evaluation of inflammasome activation with CPPD crystals

#Inflammasome Ligands

MSU Crystals - NLRP3 Inflammasome Inducer

Monosodium Urate Crystals

Evaluation of inflammasome activation with MSU Crystals

#Inflammasome Ligands

Nigericin - NLRP3 Inflammasome Inducer

Nigericin sodium salt

Induction of IL-1β secretion by monocytes upon treatment with Nigericin

#Inflammasome Ligands

Hemozoin - NLRP3 Inflammasome Inducer

Synthetic heme crystal

Induction of IL-1β secretion by monocytes upon HZ treatment

#Inflammasome Ligands

ATP - NLRP3 Inflammasome Inducer

Adenosine 5'-triphosphate disodium salt

Induction of IL-1β secretion by monocytes upon HZ treatment

#RepTor Antibiotics

Doxycycline & Blasticidin for TiGer Tet-on system

Tet-on Inducer (Doxycycline) & Selective Antibiotic (Blasticidin)

Doxycycline-mediated gene expression in HEK-RepTor™ cells

Doxycycline-mediated gene expression in A549-RepTor™ cells

#Inflammasome Ligands

LFn-Rod - Mouse NLRC4 Inflammasome Inducer

T3SS Inner Rod (PrgJ) from S. typhimurium.

Functional validation of LFn-Rod using RAW-derived cells

Murine NLRC4 inflammasome response to LFn-Rod

#Inflammasome Ligands

LFn-Needle - Human NLRC4 Inflammasome Inducer

T3SS Needle from B. thailandensis

Functional validation of LFn-Needle using THP1-derived cells

Human NLRC4 inflammasome response to LFn-Needle

#Inflammasome Ligands

Val-boroPro - NLRP1 Inflammasome Inducer, DPP8/9 inhibitor

Dipeptide boronic acid

Functional validation of Val-boroPro-induced NLRP1 inflammasome activation

#Inflammasome Ligands

Alum - NLRP3 Inflammasome Inducer

Aluminum hydroxide

Evaluation of NLRP3 inflammasome activation

Comparison of Alum Hydroxide and Alum Crystals using a cell-based assay

#Inflammasome Ligands

E. coli OMVs - Caspase 11-4/5 Inducer

E. coli outer membrane vesicles (OMVs)

Characterization of E. coli OMVs by TEM

In vitro evaluation of non-canonical caspase 4/5 inflammasome activation

In vitro evaluation of non-canonical caspase 11 inflammasome activation

In vivo evaluation of non-canonical caspase 11 inflammasome activation