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NFAT Reporter THP-1 Cells

NFAT-Lucia reporter monocytes

NFAT responses in THP1-Lucia™ NFAT cells upon stimulation with small molecules.

Dose-dependent inhibition of the calcineurin-dependent NFAT pathway using FK506

NFAT responses in THP1-Lucia™ NFAT cells

Jurkat-Raji PD-1/PD-L2 Antagonist Assay (Bio-IC™)

Two cell line bioassay - B lymphocytes & NFAT-Lucia reporter T lymphocytes

Validation of human PD-1 expression by Jurkat-Lucia™ TCR-hPD-1 cells.

Validation of human PD-L1 and PD-L2 expression by Raji-APC-hPD-L2 cells

Activation of Jurkat-Lucia™ TCR-hPD-1 cells using Anti-hPD-1 biosimilar mAbs

Activation of Jurkat-Lucia™ TCR-hPD-1 cells using Anti-hPD-L1 or Anti-hPD-L2 mAbs, alone or in combination

Jurkat-Raji (PD-1/CTLA4)/PD-L1 Antagonist Assay (Bio-IC™)

Two cell line bioassay - B lymphocytes & NFAT-Lucia reporter T lymphocytes

Validation of human CD28, CTLA4, and PD-1 expression by Jurkat-Lucia™ TCR-hCTLA4-hPD-1 cells

Validation of human CD80 and PD-L1 expression by Raji-APC-hPDL1-derived cells

Activation of Jurkat-Lucia™ TCR-hCTLA4-hPD-1 cells using Anti-hPD-1 and Anti-hCTLA4 biosimilar mAbs, alone or in combination

Jurkat-Raji CTLA4/CD80 Antagonist Assay (Bio-IC™)

Two cell line bioassay - B lymphocytes & NFAT-Lucia reporter T lymphocytes

Validation of human CD28 and CTLA4 overexpression by Jurkat-Lucia™ TCR-hCTLA4 cells

Validation of endogenous human CD80 expression by Raji-APC-Null cells

ation of Jurkat-Lucia™ TCR-hCTLA4 cells using Anti-hCTLA4 biosimilar mAb

Human CD64 (FcγRI) NFAT Reporter Jurkat Cells

NFAT-Lucia ADCP reporter T lymphocytes

Jurkat-Lucia™ NFAT-CD64 cell responses to ADCP induction

Validation of CD64 expression in Jurkat-Lucia™ NFAT-CD64 cells

Human ASC-GFP Reporter THP-1 Cells

ASC-GFP speck-forming monocytes

Visualization of ASC speck formation by fluorescence microscopy

Human IFNAR2-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

IRF INDUCTION (Lucia luciferase reporter)

NF-κB INDUCTION (SEAP reporter)

Human cGAS-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of cGAS knockout by Western blot (Wes™)

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

Human TREX1-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of TREX1 Knockout

Functional validation of TREX1 knockout (NF-κB response)

Functional validation of TREX1 knockout (IRF response)

Human STING-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Human IFI16-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of IFI16 knockout

IRF INDUCTION (Lucia luciferase reporter)

Human MyD88-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of MyD88 knockout

NF-κB responses in THP1-Dual™ KO-MyD cells

Human Caspase 1-KD THP-1 Cells

CASP1 knockdown monocytes

NFAT Reporter Jurkat Cells

NFAT-Lucia reporter T lymphocytes

Validation of human CD3 and absence of CD28 expression

NFAT activation upon stimulation using small molecules

NF-κB and ISG Dual Reporter Jurkat Cells

NF-κB-Lucia & IRF-SEAP reporter T lymphocytes

NF-κB and IRF responses of Jurkat-Dual™ Cells

NF-κB and ISG Dual Reporter THP-1 Cells - THP1-Dual™ Cells

NF-κB-SEAP and IRF-Lucia reporter monocytes

NF-κB responses in THP1-Dual™ cells

IRF responses in THP1-Dual™ cells

NF-κB Reporter THP-1 Cells (Lucia®)

NF-κB-Lucia reporter monocytes

NF-κB responses of THP1-Lucia™ NF-κB cells

ISG Reporter THP-1 Cells (SEAP)

IRF-SEAP reporter monocytes

IRF response of THP1-Blue™ ISG cells

NF-κB Reporter THP-1 Cells (SEAP)

NF-κB-SEAP reporter monocytes

NF-κB responses in THP1-Blue™ NF-κB cells

Control Reporter THP-1 Cells - THP1-Null Cells

Control monocytes