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NFAT Reporter THP-1 Cells

NFAT-Lucia reporter monocytes

NFAT responses in THP1-Lucia™ NFAT cells upon stimulation with small molecules.

Dose-dependent inhibition of the calcineurin-dependent NFAT pathway using FK506

NFAT responses in THP1-Lucia™ NFAT cells

Human ASC-GFP Reporter THP-1 Cells

ASC-GFP speck-forming monocytes

Visualization of ASC speck formation by fluorescence microscopy

Human IFNAR2-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

IRF INDUCTION (Lucia luciferase reporter)

NF-κB INDUCTION (SEAP reporter)

Human cGAS-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of cGAS knockout by Western blot (Wes™)

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

Human TREX1-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of TREX1 Knockout

Functional validation of TREX1 knockout (NF-κB response)

Functional validation of TREX1 knockout (IRF response)

Human STING-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Human IFI16-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of IFI16 knockout

IRF INDUCTION (Lucia luciferase reporter)

Human MyD88-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of MyD88 knockout

NF-κB responses in THP1-Dual™ KO-MyD cells

Human Caspase 1-KD THP-1 Cells

CASP1 knockdown monocytes

NF-κB and ISG Dual Reporter THP-1 Cells - THP1-Dual™ Cells

NF-κB-SEAP and IRF-Lucia reporter monocytes

NF-κB responses in THP1-Dual™ cells

IRF responses in THP1-Dual™ cells

NF-κB Reporter THP-1 Cells (Lucia®)

NF-κB-Lucia reporter monocytes

NF-κB responses of THP1-Lucia™ NF-κB cells

ISG Reporter THP-1 Cells (SEAP)

IRF-SEAP reporter monocytes

IRF response of THP1-Blue™ ISG cells

NF-κB Reporter THP-1 Cells (SEAP)

NF-κB-SEAP reporter monocytes

NF-κB responses in THP1-Blue™ NF-κB cells

Control Reporter THP-1 Cells - THP1-Null Cells

Control monocytes

Human NLRC4 THP-1 Cells

NLRC4 overexpressing monocytes

Inflammasome response using different Flagellins

Inflammasome response using Needle-Tox

Human MAVS-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of MAVS knockout

Functional validation of MAVS knockout (NF-κB response)

Human TLR7 Dual Reporter THP-1 Cell Lines

Two cell lines (TLR7-OE w/o TLR8) - NF-κB-SEAP & IRF-Lucia reporter human monocytes

NF-κB responses in TLR7 overexpressing THP1-Dual™ -derived cells

IRF responses in TLR7 overexpressing THP1-Dual™ -derived cells

Human MD2-CD14-TLR4/TLR4-KO Dual Reporter THP-1 Cell Lines

Two cell lines (TLR4-OE or TLR4-KO) - NF-κB-SEAP & IRF-Lucia reporter monocytes

Functional validation of NF-κB response

NF-κB responses after stimulation with rough or smooth LPS

Functional validation of IRF response

IRF responses after stimulation with rough or smooth LPS

PCR validation of TLR4 KO in THP1-Dual™ MD2-CD14 KO-TLR4 cells

Human MDA5-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of MDA5 knockout

Functional validation of MDA5 knockout (IRF response)

Functional validation of MDA5 knockout (NF-κB response)

Human STING-KI Dual Reporter THP-1 Cell Lines

Five KI-STING variants (R232, H232, M155, S154, A162) - NF-κB-SEAP & IRF-Lucia reporter monocytes

NF-κB responses in THP1-Dual™ KI-hSTING-R232 and H232 cells

IRF responses in THP1-Dual™ KI-hSTING-R232 and H232 cells

NF-κB responses in THP1-Dual™ KI-hSTING-M155 and S154 SAVI cells

IRF responses in THP1-Dual™ KI-hSTING-M155 and S154 SAVI cells

NF-κB responses in THP1-Dual™ KI-hSTING-A162 cells

IRF responses in THP1-Dual™ KI-hSTING-A162 cells