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LDH-Blue™ Cytotoxicity Assay

Lactate Dehydrogenase (LDH) Activity Assay Kit

LDH-Blue™ kit

Linear relationship between the number of lysed cells and the activity of released LDH

Pyroptotic cell death detection using LDH-Blue™

RSL3 induces LDH release in a dose-dependent manner

LDH-Blue™ allows kinetic or endpoint readings

2’3’-cGAM(PS)2 (Rp/Sp) - STING Agonist

Bisphosphorothioate analog of 2'3'-cGAMP, (Rp/Sp) cyclic [G(2’,5’)psA(3’,5’)ps]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

2’3’-cGAM(PS)2 (Rp/Sp) structure

3'3'-cGAMP Fluorinated - STING Agonist

Difluoro 3'3'-cGAMP, cyclic [FdG(3’,5’)pFdA(3’,5’)p]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

3'3'-cGAMP Fluorinated structure

2'3'-cGAMP VacciGrade™ - STING-based Adjuvant

Mammalian (non-canonical) CDN - Cyclic [G(2’,5’)pA(3’,5’)p] | Th1/Th2 response

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

2'3'-cGAMP - STING Agonist

Mammalian (non-canonical) CDN, cyclic [G(2’,5’)pA(3’,5’)p]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

c-di-AMP VacciGrade™ - STING-based Adjuvant

Cyclic diadenylate monophosphate | Th1/Th2 response

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

LPS-B5 (LPS from E. coli O55:B5) - TLR4 Agonist

Standard and ultrapure lipopolysaccharide from E. coli O55:B5

LPS-B5 Standard-dependent activation of TLR2 and TLR4

LPS-B5 UP-dependent activation of TLR4

c-di-GMP VacciGrade™ - STING-based Adjuvant

Cyclic diguanylate monophosphate | Th1/Th2 response

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

3'3'-cGAMP - STING Agonist

Bacterial (canonical) CDN, cyclic [G(3’,5’)pA(3’,5’)p]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

ADU-S100 - STING Agonist

Bisphosphorothioate analog of 2'3'-c-di-AMP, (Rp;Rp) cyclic [A(2’,5’)psA(3’,5’)ps]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

c-di-GMP - STING Agonist

Bacterial (canonical) CDN, cyclic [G(3’,5’)pG(3’,5’)p]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

c-di-AMP - STING Agonist

Bacterial (canonical) CDN, cyclic [A(3’,5’)pA(3’,5’)p]

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)

MPLA Synthetic - TLR4 Agonist

Synthetic monophosphoryl lipid A

MPLAs dose-dependent activation of TLR4

MPLA-SM - TLR4 Agonist Preparation

Monophosphoryl lipid A from Salmonella minnesota R595

Activation of mouse and human TLR4

Absence of TLR2-activating contaminants

LPS-SM (LPS from S. minnesota R595) - TLR4 Agonist

Ultrapure lipopolysaccharide from Salmonella minnesota R595

LPS-SM UP-dependent activation of TLR4

LPS-EK (LPS from E. coli K12) - TLR4 Agonist

Standard and ultrapure lipopolysaccharide from E. coli K12

LPS-EK Standard-dependent activation of TLR2 and TLR4

LPS-EK UP-dependent activation of TLR4

LPS-EB Biotin - TLR4 Agonist

Biotinylated ultrapure LPS from E. coli 0111:B4

Intracellular detection of LPS-EB Biotin (flow cytometry)

LPS-EB Biotin-dependent activation of TLR4

LPS-EB (LPS from E.coli O111:B4) - TLR4 Agonist

Standard and ultrapure lipopolysaccharide from E. coli 0111:B4

LPS-EB Standard-dependent activation of TLR2 and TLR4

LPS-EB UP-dependent activation of TLR4

LPS-PG (LPS from P. gingivalis) - TLR2/TLR4 Agonist

Lipopolysaccharide from P. gingivalis

LPS-PG Standard-dependent activation of TLR2 and TLR4

LPS-PG UP-dependent activation of TLR4

LPS-RS (LPS from R. sphaeroides) - TLR4 Antagonist

Standard and ultrapure lipopolysaccharide from R. sphaeroides

LPS-RS Standard-dependent activation of TLR2

LPS-RS Standard-dependent inhibition of LPS-induced TLR4 activation

No LPS-RS UP-dependent activation of TLR2 and TLR4

LPS-RS UP-dependent inhibition of LPS-induced TLR4 activation