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#Custom Services

Custom Cell Line Development Service

Our custom cell line development service is designed to support your specific experimental goals

Overexpression confirmation

Biological activity validation

Stability testing

#Custom Services

PRR Compound Screening and Profiling

Our screening service can assess activation or inhibition of innate immune pathways by pattern recognition receptors

Level 1 Compound Profiling Example Figure

Level 2 Compound Dose Response Example Figure

#Custom Services

Custom Cloning Service

Specialized plasmids designed to meet your unique experimental needs

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#Custom Services

Cytokines Compound Screening

Our profiling service enables the detection of bioactive effects in your samples.

Dose-response of HEK-Blue™-derived cells to compound of interest

Dose-dependent inhibition of HEK-Blue™-derived cell response using the compound of interest

Poly(I:C) (HMW) Cy5 - TLR3 agonist

Cy5-labeled poly(I:C) (HMW)

Validation of Cy5 fluorescent labeling by fluorescence microscopy

Validation of Cy5 fluorescent labeling by flow cytometry

Dose-dependent activation of TLR3 with Poly(I:C) Cy5

Poly(I:C) (HMW) Cy3 - TLR3 agonist

Cy3-labeled poly(I:C) (HMW)

Validation of Cy3 fluorescent labeling by flow cytometry

Validation of Cy3 fluorescent labeling by fluorescence microscopy

Dose-dependent activation of TLR3 with Poly(I:C) Cy3

Poly(I:C) (LMW) Rhodamine - TLR3 Agonist

Rhodamine-labeled poly(I:C) (LMW)

Dose-dependent response to Poly(I:C) (LMW) Rhodamine in HEK-Blue™ hTLR3 cells

Poly(I:C) (HMW) Biotin -TLR3 Agonist

Biotin-labeled poly(I:C) (HMW)

TLR3 activation by Poly(I:C) HMW Biotin

Binding of Poly(I:C) HMW Biotin to TLR3

#Reporter Detection Reagents

HEK-Blue™ Detection - SEAP Detection Medium

Cell culture medium for real-time SEAP detection

HEK-Blue™ Detection by InvivoGen

Poly(I:C) (LMW) / LyoVec™ - RIG-I/MDA-5 Agonist

dsRNA - complexed with transfection reagent

Dose-dependent interferon regulatory factor (IRF) response to Poly(I:C) (LMW) / LyoVec™ in A549-Dual™ cells.

Poly(I:C) (HMW) / LyoVec™ - RIG-I/MDA5 Agonist

LyoVec™ complexed

Dose-dependent interferon regulatory factor (IRF) response to Poly(I:C) (HMW) / LyoVec™ in A549-Dual™ cells.

#Reporter Detection Reagents

QUANTI-Luc™: Luciferase Detection Reagent

Luminescence detection kit for standard and HTS assays

Lucia luciferase detection for 10 min using QUANTI-Luc™ 4 Lucia/Gaussia

Lucia luciferase end-point detection using QUANTI-Luc™ 4 Lucia/Gaussia

Renilla luciferase detection for 20 min using QUANTI-Luc™ 4 Renilla

Renilla luciferase end-point detection using QUANTI-Luc™ 4 Renilla

#Reporter Detection Reagents

Recombinant Lucia® Luciferase Protein - Positive Control

Positive control for luciferase reporter assays

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#Reporter Detection Reagents

Recombinant SEAP Protein - Positive Control

Positive control for SEAP reporter assays

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#Reporter Detection Reagents

QUANTI-Blue™ - SEAP Detection Reagent

Alkaline phosphatase detection reagent

QUANTI-Blue™ Standard procedure

QUANTI-Blue™ High Throughput Screening (HTS) procedure

Poly(A:U) - TLR3 Agonist

Polyadenylic-polyuridylic acid

Poly(I:C) (HMW) Fluorescein - TLR3 Agonist

Fluorescent-labeled poly(I:C) (HMW)

Dose-dependent response to Poly(I:C) (HMW) Fluorescein in HEK-Blue™ hTLR3 cells

Poly(I:C) (HMW) Rhodamine - TLR3 Agonist

Rhodamine-labeled poly(I:C) (HMW)

Dose-dependent response to Poly(I:C) (HMW) Rhodamine in HEK-Blue™ hTLR3 cells

Poly(I:C) LMW - TLR3 Agonist

Low molecular weight polyinosine-polycytidylic acid

Dose-dependent activation of TLR3

Poly(I:C) HMW - TLR3 Agonist

High molecular weight polyinosine-polycytidylic acid

Dose-dependent activation of TLR3