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#Custom Services

Custom Cell Line Development Service

Our custom cell line development service is designed to support your specific experimental goals

Overexpression confirmation

Biological activity validation

Stability testing

#Custom Services

PRR Compound Screening and Profiling

Our screening service can assess activation or inhibition of innate immune pathways by pattern recognition receptors

Level 1 Compound Profiling Example Figure

Level 2 Compound Dose Response Example Figure

#Custom Services

Custom Cloning Service

Specialized plasmids designed to meet your unique experimental needs

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#Custom Services

Cytokines Compound Screening

Our profiling service enables the detection of bioactive effects in your samples.

Dose-response of HEK-Blue™-derived cells to compound of interest

Dose-dependent inhibition of HEK-Blue™-derived cell response using the compound of interest

TDB - Mincle Agonist

Synthetic analog of the cord factor

TDB dose-dependent activation of Mincle

NF-κB response to various Mincle agonists in HEK-Blue™ hMincle cells

#TLR-NOD (Kits) Ligands

Mouse TLR9 Agonist Kit

Set of known agonists for mouse TLR9

Dose-dependent NF-κB response of ODN 1585 in HEK-Blue™ mTLR9 cells

NF-κB response of ODN 1826 in HEK-Blue™-derived cells

NF-κB response in HEK-Blue™-derived cells upon ODN 2395 stimulation

#TLR-NOD (Kits) Ligands

Human TLR9 Agonist Kit

Set of known agonists for human TLR9

Dose-dependent NF-κB response of ODN 2216 in HEK-Blue™ hTLR9 cells

Dose-dependent NF-κB response in HEK-Blue™ hTLR9 cells.

NF-κB responses in HEK-Blue™ mTLR9 cells

#TLR-NOD (Kits) Ligands

Human TLR3/7/8/9 Agonist kit

14 ligands for human TLR3, TLR7, TLR8 and TLR9

Response of HEK-Blue™-derived cells to TLR3 agonists

NF-κB response of HEK-Blue™-derived cells to R848

NF-κB response of HEK-Blue™-derived cells to ssRNA40/LyoVec™

Dose-dependent NF-κB response in HEK-Blue™ hTLR9 cells.

#TLR-NOD (Kits) Ligands

Mouse TLR1-9 Agonist kit

9 ligands for murine TLR1 to TLR9

Evaluation of NF-κB activation with Pam3CSK4

Dose-dependent activation of TLR3

LPS-EK Standard-dependent activation of TLR2 and TLR4

NF-κB response of ODN 1826 in HEK-Blue™-derived cells

#TLR-NOD (Kits) Ligands

Human TLR1-9 Agonist kit

10 ligands for human TLR1 to TLR9

Dose-dependent activation of TLR2 by FSL-1

Dose-dependent activation of TLR3

LPS-EK Standard-dependent activation of TLR2 and TLR4

NF-κB response induced by ODN 2006

HKCA - Dectin-1 Agonist

Heat-killed Candida albicans

HKCA dose-dependent activation of Dectin-1

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Curdlan - Dectin-1 Agonist

Beta-1,3-glucan from Alcaligenes faecalis

Curdlan dose-dependent activation of Dectin-1

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Partial structure of Curdlan

Depleted Zymosan - Dectin-1 Agonist

Hot alkali–treated zymosan — Selective Dectin-1 agonist, depleted of TLR2 activity

Zymosan Depleted dose-dependent activation of Dectin-1

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Furfurman - Dectin-2 Agonist

Malassezia furfur cell wall preparation

Furfurman dose-dependent activation of Dectin-2

Laminarin - Dectin-1 Ligand

Soluble beta-glucan from Laminaria digitata - Dectin-1 Antagonist or Agonist

Laminarin dose-dependent activation of Dectin-1a

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Partial structure of Laminarin

Zymosan - TLR2 & Dectin-1 Agonist

Cell wall preparation of S. cerevisiae

Zymosan dose-dependent activation of Dectin-1, TLR2, and TLR4

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Whole Glucan Particles (WGP) - Dectin-1 Ligand

WGP Dispersible and WGP Soluble (Control)

WGP Dispersible dose-dependent activation of Dectin-1a

WGP Soluble dose-dependent activation of Dectin-1a

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

β-GlcCer - Mincle Agonist

C24:1 Glucosyl(β) Ceramide

β-GlcCer dose-dependent activation of Mincle

NF-κB response to various Mincle agonists in HEK-Blue™ hMincle cells

HKMT - Mincle & TLR2 Agonist

Heat-killed Mycobacterium tuberculosis

HKMT dose-dependent activation of TLR2 and Mincle

NF-κB response to various Mincle agonists in HEK-Blue™ hMincle cells

Pustulan - Dectin-1 Agonist

Beta-D-glucan from lichen Lasallia pustulata

Pustulan dose-dependent activation of Dectin-1

NF-κB response to various Dectin-1 agonists in HEK-Blue™ hDectin-1a cells

Partial structure of Pustulan