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The Third International DAMPs and Alarmins Symposium was held in Pittsburgh, USA in 2008. The aim of this meeting was to introduce the emergent understanding of the danger signals also called alarmins or damage associated molecular patterns (DAMPs) by analogy to the pathogen associated molecular patterns (PAMPs). # Review Type I IFN Production and Signaling The most studied members of the Type I family of interferons are the multiple IFNα isotypes and IFNβ. Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections, as well as activating key components of the innate and adaptive immune systems including antigen presentation and production of cytokines involved in activation of T cells, B cells, and natural killer cells. # Review Toll-Like Receptors and Viral Infection Toll-like receptors (TLRs) are essential for the recognition of microbial pathogens. A subset of TLRs, TLR3, TLR7/8, and TLR9, is involved in antiviral responses by triggering the production of antiviral cytokines such as type I interferons (IFNs). # Newsletter & guide TLR3: racing for vaccine advantages Toll-like receptors (TLRs) play a pivotal role in the initiation of prompt innate immune defenses, as well as in the activation of adaptive immune cells for enhanced and memory responses. (...) # Newsletter & guide TLR7 and TLR8: same... but different! The innate immune system is armed with a limited set of germline-encoded pattern recognition receptors (PRRs) capable of sensing a tremendous variety of potential pathogens. (...) # Newsletter & guide NLRP1 & NLRP3: a tale of two inflammasome sensors Early 2000s, NLRP1 and NLRP3 were the first described inflammasomes, consisting in cytosolic multi-protein complexes that sense danger signals. (...) # Newsletter & guide Cell culture Contamination Whether remaining unnoticed or expanding rapidly, microbes can seriously alter cell morphology and functions, becoming a serious threat to your research. InvivoGen offers microbial detection tools and elimination reagents, as well as preventive tips. xxx (...) # Newsletter & guide Inflammasomes - Practical guide InvivoGen offers a comprehensive collection of tools to assist your research on these inflammatory signaling hubs. (...) # Newsletter & guide The race against SARS-CoV-2 variants The ongoing COVID-19 pandemic has had a devastating global impact on public health, the economy and society. (...) # Newsletter & guide Mouse Anti-Mouse mAbs & COVID-19 Related Cell Lines In this insight newsletter, we highlight two unrelated product ranges. The first is a growing collection of monoclonal antibodies optimized for in vivo mouse studies. The second is a new series of COVID-19 related cell lines, specifically designed for developing novel therapeutics against SARS-CoV-2. (...) # Newsletter & guide TLR7 & TLR8: fraternal twins Toll-like receptors (TLRs) play a pivotal role in the initiation of anti-infectious immune responses. (...) # Newsletter & guide NLRP3: a sophisticated drug target NLRP3 (NOD-like receptor pyrin domain-containing protein 3, cryopyrin or NALP3) is the best described inflammasome sensor and an attractive drug target. (...) # Newsletter & guide RIG-I & cancer immunotherapy The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer immunotherapy, although complete remission remains limited to a small panel of cancers and patients. (...) # Newsletter & guide Immune Checkpoint Blockade: InestimAble Advances Over the last decade, the understanding of key steps in the regulation of T cell responses has led to the groundbreaking development of immune checkpoint blocking monoclonal antibodies (mAbs) to fight cancer. (...) # Newsletter & guide AhR's key role in the intestinal microbiota and immunity The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcriptional factor widely expressed among immune, epithelial, endothelial and stromal cells in barrier tissues. (...) Pagination First page « First Previous page ‹ Previous … Page 126 Page 127 Page 128 Page 129 Page 130 Page 131 Page 132 Page 133 Page 134 Next page Next › Last page Last »
# Review Recognition of Cytosolic DNA The innate immune system reacts to diverse molecules of microbial origin, termed pathogen-associated molecular patterns (PAMPs), or released from damaged or dying cells, called damage-associated molecular patterns (DAMPs).
# Review Damage-associated molecular patterns Damage-associated molecular patterns (DAMPs), also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the inflammatory response.
# Review Engineered Fc Regions The Fc region of an antibody mediates its serum half-life and effector functions, such as complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell phagocytosis (ADCP).
# Review CpG-free DNA Review Review of the effect of CpG dinucleotide on the immune response and the gene silencing of gene delivery vectors for gene therapy applications.
# Review Activation of the NLRP3 Inflammasome The inflammasome is a large multiprotein complex which plays a key role in innate immunity by participating in the production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18.
# Review DAMPs: Endogenous Ligands of TLRs? The Third International DAMPs and Alarmins Symposium was held in Pittsburgh, USA in 2008. The aim of this meeting was to introduce the emergent understanding of the danger signals also called alarmins or damage associated molecular patterns (DAMPs) by analogy to the pathogen associated molecular patterns (PAMPs).
# Review Type I IFN Production and Signaling The most studied members of the Type I family of interferons are the multiple IFNα isotypes and IFNβ. Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections, as well as activating key components of the innate and adaptive immune systems including antigen presentation and production of cytokines involved in activation of T cells, B cells, and natural killer cells.
# Review Toll-Like Receptors and Viral Infection Toll-like receptors (TLRs) are essential for the recognition of microbial pathogens. A subset of TLRs, TLR3, TLR7/8, and TLR9, is involved in antiviral responses by triggering the production of antiviral cytokines such as type I interferons (IFNs).
# Newsletter & guide TLR3: racing for vaccine advantages Toll-like receptors (TLRs) play a pivotal role in the initiation of prompt innate immune defenses, as well as in the activation of adaptive immune cells for enhanced and memory responses. (...)
# Newsletter & guide TLR7 and TLR8: same... but different! The innate immune system is armed with a limited set of germline-encoded pattern recognition receptors (PRRs) capable of sensing a tremendous variety of potential pathogens. (...)
# Newsletter & guide NLRP1 & NLRP3: a tale of two inflammasome sensors Early 2000s, NLRP1 and NLRP3 were the first described inflammasomes, consisting in cytosolic multi-protein complexes that sense danger signals. (...)
# Newsletter & guide Cell culture Contamination Whether remaining unnoticed or expanding rapidly, microbes can seriously alter cell morphology and functions, becoming a serious threat to your research. InvivoGen offers microbial detection tools and elimination reagents, as well as preventive tips. xxx (...)
# Newsletter & guide Inflammasomes - Practical guide InvivoGen offers a comprehensive collection of tools to assist your research on these inflammatory signaling hubs. (...)
# Newsletter & guide The race against SARS-CoV-2 variants The ongoing COVID-19 pandemic has had a devastating global impact on public health, the economy and society. (...)
# Newsletter & guide Mouse Anti-Mouse mAbs & COVID-19 Related Cell Lines In this insight newsletter, we highlight two unrelated product ranges. The first is a growing collection of monoclonal antibodies optimized for in vivo mouse studies. The second is a new series of COVID-19 related cell lines, specifically designed for developing novel therapeutics against SARS-CoV-2. (...)
# Newsletter & guide TLR7 & TLR8: fraternal twins Toll-like receptors (TLRs) play a pivotal role in the initiation of anti-infectious immune responses. (...)
# Newsletter & guide NLRP3: a sophisticated drug target NLRP3 (NOD-like receptor pyrin domain-containing protein 3, cryopyrin or NALP3) is the best described inflammasome sensor and an attractive drug target. (...)
# Newsletter & guide RIG-I & cancer immunotherapy The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer immunotherapy, although complete remission remains limited to a small panel of cancers and patients. (...)
# Newsletter & guide Immune Checkpoint Blockade: InestimAble Advances Over the last decade, the understanding of key steps in the regulation of T cell responses has led to the groundbreaking development of immune checkpoint blocking monoclonal antibodies (mAbs) to fight cancer. (...)
# Newsletter & guide AhR's key role in the intestinal microbiota and immunity The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcriptional factor widely expressed among immune, epithelial, endothelial and stromal cells in barrier tissues. (...)
