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#TLR7/8 Ligands

ssRNA40/LyoVec™ - TLR7/8 Agonist

HIV-1-derived ssRNA / LyoVec™ complexed

NF-κB response of HEK-Blue™-derived cells to ssRNA40/LyoVec™

#TLR7/8 Ligands

ssPolyU/LyoVec™ - TLR8 Agonist

RNA homopolymer / LyoVec™ complexed

NF-κB response of HEK-Blue™-derived cells to ssPolyU/LyoVec™

G140 - Human cGAS inhibitor

InvitroFit™ PRR inhibitor

G140 inhibits human cGAS-induced IRF signaling

G140 inhibits human cGAS-induced NF-κB signaling

Specific inhibition of cGAS by G140

G140 does not inhibit STING signaling

B18R recombinant protein - IFN-α/β inhibitor

InvitroFit™ Interferon inhibitor

Recombinant B18R is a potent inhibitor of human IFN-α

Enhanced mRNA transfection in THP-1 cells using B18R

NT-0796 - NLRP3 Inhibitor

InvitroFit™ Inflammasome inhibitor

Specific inhibition of NLRP3 by NT-0796

Dose-dependent inhibition of NLRP3-dependent IL-1β release

TDI-6570 - Mouse cGAS Inhibitor

InvitroFit™ PRR inhibitor

Dose-dependent inhibition of mouse cGAS

Inhibitory effect of TDI-6570 on human cGAS

M5049 (Enpatoran) - TLR7/TLR8 Inhibitor

Quinoline compound - CAS #2101938-42-3 - InvitroFit™ PRR inhibitor

Inhibition of TLR7/8 signaling in HEK cells

Inhibition of TLR7/8 signaling in THP1 cells

Specific inhibition of TLR7 and TLR8 signaling by M5049

Chemical structure of M5049 (Enpatoran)

TL2-C29 - TLR2 signaling inhibitor

InvitroFit™ PRR inhibitor

Dose-dependent inhibition of TLR2 signaling

Specific inhibition of TLR2 signaling

Dose-dependent inhibition of TLR2/1 and TLR2/6 signaling

#TLR7/8 Ligands

TL7-887 (maleimide) and TL7-975 (azido) - Conjugatable TLR7 Ligands

Conjugatable adenine analogs

Biological activity of TL7-887

Biological activity of Anti-TROP2/TL7-887 in co-cultures

Biological activity of TL7-975

Biological activity of TL7-975 conjugated to Anti-HER2-hIgG1

EK1C4 - Pan-Coronavirus Fusion Inhibitor

InvitroFit™ COVID-19-related inhibitor

Dose-dependent inhibition of cell-cell fusion

BMS-986256 (Afimetoran) - TLR7/TLR8 Inhibitor

Indole compound - CAS #2171019-55-7 - InvitroFit™ PRR inhibitor

Inhibition of TLR7/8 signaling in HEK cells

Inhibition of TLR7/8 signaling in THP1 cells

Specific inhibition of TLR7 and TLR8 signaling by BMS-986256

Z-IETD-FMK - Caspase-8 Inhibitor

InvitroFit™ Cell death modulator

Dose-dependent induction of necroptosis

BV6 - IAP Inhibitor

InvitroFit™ Cell death modulator

Dose-dependent induction of necroptosis

Necrostatin-1 - RIPK1 Inhibitor

InvitroFit™ Cell death modulator

Dose-dependent inhibition of RIPK1 activity

MRT67307 - TBK1/IKKε Inhibitor

InvitroFit™ PRR inhibitor

Inhibition of 3p-hpRNA and 2’3-cGAMP-induced responses in THP1-Dual™ Cells

Inhibition of 3p-hpRNA-induced responses in THP1-Dual™ Cells

RU.521 - Mouse cGAS Inhibitor

InvitroFit™ PRR inhibitor

Dose-dependent inhibition of cGAS

Assessment of inhibition by RU.521

H151 - STING inhibitor

InvitroFit™ PRR inhibitor

Dose-dependent inhibition of STING-IRF activity by H-151

Specific inhibition of STING-IRF activity by H-151

Inhibition of IRF activity in STING variants by H-151

Dose-dependent inhibition of STING-NF-κB activity by H-151

CH-223191 - AhR Antagonist

InvitroFit™ PRR inhibitor

Evaluation of cellular AhR inhibition by CH-223191

CU-CPT9a - TLR8 Inhibitor

Quinoline compound - CAS #2165340-32-7 - InvitroFit™ PRR inhibitor

CU-CPT9a inhibits hTLR8 in a dose-dependent response

Specific inhibition of TLR8 by CU-CPT9a

Brefeldin A - STING Trafficking Inhibitor

InvitroFit™ PRR inhibitor

BFA inhibits STING-induced IRF activity

Brefeldin A inhibits STING protein translocation