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#Custom Services

Custom Cell Line Development Service

Our custom cell line development service is designed to support your specific experimental goals

Overexpression confirmation

Biological activity validation

Stability testing

#Custom Services

PRR Compound Screening and Profiling

Our screening service can assess activation or inhibition of innate immune pathways by pattern recognition receptors

Level 1 Compound Profiling Example Figure

Level 2 Compound Dose Response Example Figure

#Custom Services

Custom Cloning Service

Specialized plasmids designed to meet your unique experimental needs

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VET-SAP® saponin adjuvant

Saponin vaccine adjuvant - CAS #8047-15-2

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#Custom Services

Cytokines Compound Screening

Our profiling service enables the detection of bioactive effects in your samples.

Dose-response of HEK-Blue™-derived cells to compound of interest

Dose-dependent inhibition of HEK-Blue™-derived cell response using the compound of interest

CL429 VacciGrade™ - TLR2 & NOD2-based Adjuvant

Pam2C-conjugated murabutide

Dose-dependent NF-κB response to CL429 in HEK-Blue™ hTLR2 and HEK-Blue™ hNOD2 cells

CL429 chemical structure

Pam3CSK4 VacciGrade™ - TLR2/TLR1-based Adjuvant

Synthetic triacylated lipopeptide | Th1 response

Evaluation of NF-κB activation with Pam3CSK4

Specificity of Pam3CSK4 activation

ODN 1585 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class A (Mouse) | Th1 response

Dose-dependent NF-κB response of ODN 1585 in HEK-Blue™ mTLR9 cells

NF-κB and IRF responses of ODN 1585 in THP1-Dual™ hTLR9 cells

CL413 VacciGrade™ - TLR2 & TLR7-based Adjuvant

Chimeric molecule | Th1/Th2 response

Tumor growth after CL413 or CL401 treatment

Survival curves for untreated as well as CL413- or CL401-treated mice

CL413 chemical structure

CL401 VacciGrade™ - TLR2 & TLR7-based Adjuvant

Pam2C-conjugated 8-hydroxyadenine| Th1/Th2 response

Tumor growth after CL413 or CL401 treatment

Survival curves for untreated as well as CL413- or CL401-treated mice

Anti-OVA mIgG levels at 15, 30 and 45 days after the initial immunization in different groups.

Anti-OVA total IgG, IgG1, and IgG2a levels 45 days after the initial immunization in different groups.

#Antibiotics Selection

HEK-Blue™ CLR Selection

Antibiotics for maintenance of HEK-Blue™ Dectin & Mincle cells

Recommended use of HEK-Blue™ CLR Selection

Quil-A® adjuvant

Saponin vaccine adjuvant

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#Antibiotics Selection

Zeocin®

Selective antibiotic for the Sh ble gene

Zeocin® by InvivoGen

#Antibiotics Selection

Puromycin

Selective antibiotic for the pac gene

Puromycin by InvivoGen

Chemical structure of Puromycin

#Antibiotics Selection

Phleomycin

Selective antibiotic for the Sh ble gene

Phleomycin by InvivoGen

#Antibiotics Selection

Hygromycin B Gold

Selective antibiotic for the hph gene

Hygromycin B Gold™ by InvivoGen

Chemical structure of Hygromycin

#Antibiotics Selection

G418 (Geneticin)

Selective antibiotic for the neo gene

G418 (Geneticin) by InvivoGen

Chemical structure of G418 (Geneticin)

LPS-EB VacciGrade™ - TLR4-based Adjuvant

Lipopolysaccharide from E. coli 0111:B4 | Th1 response

LPS-EB Vaccigrade™-dependent activation of TLR4

TDB VacciGrade™ - Mincle-based Adjuvant

Synthetic analog of the cord factor | Th1 response

TDB dose-dependent activation of Mincle

ODN 2395 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class C (Human/mouse) | Th1 response

NF-κB response in HEK-Blue™-derived cells upon ODN 2395 stimulation

NF-κB and IRF response upon ODN 2395 stimulation