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Human ASC-GFP Reporter THP-1 Cells

ASC-GFP speck-forming monocytes

Visualization of ASC speck formation by fluorescence microscopy

Human STING-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Human IFI16-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of IFI16 knockout

IRF INDUCTION (Lucia luciferase reporter)

Human MyD88-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of MyD88 knockout

NF-κB responses in THP1-Dual™ KO-MyD cells

Human Caspase 1-KD THP-1 Cells

CASP1 knockdown monocytes

NF-κB Reporter THP-1 Cells (Lucia®)

NF-κB-Lucia reporter monocytes

NF-κB responses of THP1-Lucia™ NF-κB cells

NF-κB Reporter THP-1 Cells (SEAP)

NF-κB-SEAP reporter monocytes

NF-κB responses in THP1-Blue™ NF-κB cells

Control Reporter THP-1 Cells - THP1-Null Cells

Control monocytes

Human NLRC4 THP-1 Cells

NLRC4 overexpressing monocytes

Inflammasome response using different Flagellins

Inflammasome response using Needle-Tox

Human TLR7 Dual Reporter THP-1 Cell Lines

Two cell lines (TLR7-OE w/o TLR8) - NF-κB-SEAP & IRF-Lucia reporter human monocytes

NF-κB responses in TLR7 overexpressing THP1-Dual™ -derived cells

IRF responses in TLR7 overexpressing THP1-Dual™ -derived cells

Human MD2-CD14-TLR4/TLR4-KO Dual Reporter THP-1 Cell Lines

Two cell lines (TLR4-OE or TLR4-KO) - NF-κB-SEAP & IRF-Lucia reporter monocytes

Functional validation of NF-κB response

NF-κB responses after stimulation with rough or smooth LPS

Functional validation of IRF response

IRF responses after stimulation with rough or smooth LPS

PCR validation of TLR4 KO in THP1-Dual™ MD2-CD14 KO-TLR4 cells

Human MDA5-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of MDA5 knockout

Functional validation of MDA5 knockout (IRF response)

Functional validation of MDA5 knockout (NF-κB response)

IKK epsilon-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter human monocytes - IKKε deficient

Validation of IKKε KO by PCR and Western blot

Functional validation of IKKε knockout (NF-κB and IRF response)

RNA-induced responses in THP1-Dual™ KO-IKKε cells

Human TRIF-KO Dual Reporter THP-1 Cells

NF-κB-SEAP and IRF-Lucia reporter monocytes

Validation of TRIF KO

IRF responses in PMA-differentiated THP1-Dual™ KO-TRIF cells

NF-κB responses in PMA-differentiated THP1-Dual™ KO-TRIF cells

Human DNase2-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of DNASE2 knockout

Functional validation of DNASE2 knockout (NF-κB response)

Functional validation of DNASE2 knockout (IRF response)

Human IRF7-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of IRF7 KO

Functional validation of IRF7 knockout (NF-κB response)

Functional validation of IRF7 knockout (IRF response)

Human IRF5-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of IRF5 KO

Functional validation of IRF5 knockout (NF-κB response)

Functional validation of IRF5 knockout (IRF response)

Human Caspase 4-KO THP-1 Cells

CASP4-KO monocytes

Validation of CASP4 KO in THP1-KO-CASP4 cells

Secretion of mature IL-1β by THP1-KO-CASP4 cells

Human ASC-KO THP-1 Cells

ASC-KO monocytes

Validation of ASC KO in THP1-KO-ASC cells

Absence of mature IL-1β secretion by THP1-KO-ASC cells

Absence of pyroptosis in THP1-KO-ASC cells

Human NLRP3-KO THP-1 Cells

NLRP3-KO monocytes

Validation of NLRP3 KO in THP1-KO-NLRP3 cells

Absence of mature IL-1β secretion in THP1-KO-NLRP3 cells

Absence of pyroptosis in THP1-KO-NLRP3 cells (LDH read-out)