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#Reporter Detection Vectors

pNiFty3-SEAP

Inducible SEAP reporter plasmid - mIFN-β promoter - ZeocinR

pNiFty3 map

#Reporter Detection Vectors

pNiFty2-IFA

Inducible SEAP reporter plasmid- mIFNα promoter - Zeocin® resistance

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ODN TTAGGG (A151) - TLR9 Antagonist

TLR9, AIM2, and cGAS antagonist

TLR9 signaling inhibition

Specific AIM2 inflammasome signaling inhibition

CDS signaling inhibition

ODN 4084-F - TLR9 Antagonist

Class B inhibitory ODN

Dose-dependent inhibition of TLR9 activity by ODN 4084-F

ODN 2088 control - TLR9 Ligand

Negative control for ODN 2088

Dose-dependent inhibition of TLR9 activity in HEK-Blue™ mTLR9 cells.

ODN 2088 - TLR9 Antagonist

Inhibitory ODN, preference towards mouse

Dose-dependent inhibition of TLR9 activity by ODN 2088

ODN 1585 - TLR9 Agonist

Stimulatory CpG ODN, Class A, Mouse-preferred

Dose-dependent NF-κB response of ODN 1585 in HEK-Blue™ mTLR9 cells

NF-κB and IRF responses of ODN 1585 in THP1-Dual™ hTLR9 cells

E. coli ssDNA / LyoVec™ - TLR9 Agonist

E. coli single stranded DNA / LyoVec™ complexed

Dose-dependent response of E. coli ssDNA/LyoVec™ in THP1-Blue™ ISG cells

ODN TTAGGG control - TLR9 Ligand

Negative control for ODN TTAGGG

Dose-dependent inhibition of TLR9 activity in HEK-Blue™ hTLR9 cells

ODN 1826 FITC - TLR9 Agonist

FITC-labeled CpG ODN, Class B, Mouse-preferred

Detection of ODN 1826 FITC

ODN 1826 Biotin - TLR9 Agonist

Biotin-labeled CpG ODN 1826, Class B, Mouse-preferred

Detection of ODN 1826 Biotin

ODN 1826 control (ODN 2138) - TLR9 Ligand

Negative control for ODN 1826

Dose-dependent NF-κB response in HEK-Blue™ mTLR9 cells.

ODN 1826 - TLR9 Agonist

Stimulatory CpG ODN, Class B, Mouse-preferred

NF-κB response of ODN 1826 in HEK-Blue™-derived cells

NF-κB and IRF responses of ODN 1826 in THP1-Dual™ hTLR9 cells

ODN 1668 - TLR9 Agonist

CpG ODN, Class B (Mouse)

Dose-dependent NF-κB response of ODN 1668 in HEK-Blue™ mTLR9 cells

ODN 2006 control (ODN 2137) - TLR9 Ligand

Negative control for ODN 2006

Dose-dependent NF-κB response in HEK-Blue™ hTLR9 cells.

ODN 2006 (ODN 7909) - TLR9 Agonist

Stimulatory CpG ODN, Class B, Human-preferred

Species-driven TLR9 differential responses

NF-κB response induced by ODN 2006

IRF response induced by ODN 2006

ODN 2395 control - TLR9 Ligand

Negative control for ODN 2395, Class C, Human/mouse-preferred

NF-κB responses in HEK-Blue™ mTLR9 cells

ODN 2395 - TLR9 Agonist

Stimulatory CpG ODN, Class C, Human/Mouse-preferred

NF-κB response in HEK-Blue™-derived cells upon ODN 2395 stimulation

NF-κB and IRF response upon ODN 2395 stimulation

ODN 2336 - TLR9 Agonist

CpG ODN, Class A (Human)

NF-κB and IRF responses induced by ODN 2336

ODN M362 - TLR9 Agonist

CpG ODN, Class C (Human/mouse)

Dose-dependent NF-κB response of ODN M362 in HEK-Blue™ mTLR9 cells