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RSL3 - GPX4 inhibitor & Ferroptosis inducer

Invitrofit™ Cell death modulator

RSL3 chemical structure

Ferroptosis induction by RSL3 (LDH readout)

Ferroptosis induction by RSL3 (HMGB1-Lucia readout)

Ferrostatin-1 - Ferroptosis inhibitor

InvitroFit™ Cell death modulator

Ferrostatin-1 chemical formula

Ferroptosis inhibition by Ferrostatin-1 (LDH readout)

Ferroptosis inhibition by Ferrostatin-1 (HMGB1-Lucia readout)

CL429 VacciGrade™ - TLR2 & NOD2-based Adjuvant

Pam2C-conjugated murabutide

Dose-dependent NF-κB response to CL429 in HEK-Blue™ hTLR2 and HEK-Blue™ hNOD2 cells

CL429 chemical structure

ODN 1585 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class A (Mouse) | Th1 response

Dose-dependent NF-κB response of ODN 1585 in HEK-Blue™ mTLR9 cells

NF-κB and IRF responses of ODN 1585 in THP1-Dual™ hTLR9 cells

LL-37 - TLR2 and TLR4 Signaling Inhibitor

InvitroFit™ PRR inhibitor

Dose-dependent inhibition of TLR4 activity

Pepinh-TRIF - TRIF Inhibitor

PRR inhibitor

Inhibitory activities of Pepinh-MYD and Pepinh-TRIF

Pepinh-MYD - MyD88 Inhibitor

PRR inhibitor

Inhibitory activities of Pepinh-MYD and Pepinh-TRIF

TDB VacciGrade™ - Mincle-based Adjuvant

Synthetic analog of the cord factor | Th1 response

TDB dose-dependent activation of Mincle

ODN 2395 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class C (Human/mouse) | Th1 response

NF-κB response in HEK-Blue™-derived cells upon ODN 2395 stimulation

NF-κB and IRF response upon ODN 2395 stimulation

R848 VacciGrade™ - TLR7/8-based Adjuvant

Imidazoquinoline compound | Th1 response

NF-κB response of HEK-Blue™-derived cells to R848

NF-κB and IRF responses of THP1-Dual™-derived cells to R848

Poly(I:C) (HMW) VacciGrade™ - TLR3-based Adjuvant

Polyinosine-polycytidylic acid | Th1 response

Dose-dependent activation of TLR3

ODN 2216 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class A (Human) | Th1 response

Dose-dependent NF-κB response of ODN 2216 in HEK-Blue™ hTLR9 cells

Dose-dependent NF-κB and IRF responses in THP1-Dual™ hTLR9 cells

ODN 1826 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class B (Mouse) | Th1 response

NF-κB response of ODN 1826 in HEK-Blue™-derived cells

NF-κB and IRF responses of ODN 1826 in THP1-Dual™ hTLR9 cells

Imiquimod VacciGrade™ (R837) - TLR7-based Adjuvant

Imidazoquinoline compound | Th1 response

NF-κB response of HEK-Blue™-derived cells to imiquimod

NF-κB and IRF responses of HEK-Dual™-derived cells to imiquimod

MPLA Synthetic VacciGrade™ - TLR4-based Adjuvant

Synthetic monophosphoryl lipid A | Th1 response

MPLAs dose-dependent activation of TLR4

G140 - Human cGAS inhibitor

InvitroFit™ PRR inhibitor

G140 inhibits human cGAS-induced IRF signaling

G140 inhibits human cGAS-induced NF-κB signaling

Specific inhibition of cGAS by G140

G140 does not inhibit STING signaling

NexaVant™ VacciGrade™ - TLR3 & dsRNA-based Vaccine Adjuvant

Synthetic double stranded RNA | Th1 response

Molecular weight of NexaVant™ (agarose gel)

TLR3 response HEK-Blue™ hTLR3 cells to NexaVant™

IgG level in serum of mice after intramuscular administration

Antigen-specific T cell responses after NexaVant™ treatment

ODN 1018 VacciGrade™ - TLR9-based Adjuvant

CpG ODN, Class B (Human/mouse) | Th1 response

Murine and human TLR9 activation in HEK-Blue™-derived cells

H151 - STING inhibitor

InvitroFit™ PRR inhibitor

Dose-dependent inhibition of STING-IRF activity by H-151

Specific inhibition of STING-IRF activity by H-151

Inhibition of IRF activity in STING variants by H-151

Dose-dependent inhibition of STING-NF-κB activity by H-151

2'3'-c-di-AM(PS)2 (Rp,Rp) VacciGrade™ - STING-based Adjuvant

Analog of c-di-AMP | Th1/Th2 response

IRF INDUCTION (Lucia luciferase reporter)

NF-kB INDUCTION (SEAP reporter)