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Human TLR7 Dual Reporter THP-1 Cell Lines

Two cell lines (TLR7-OE w/o TLR8) - NF-κB-SEAP & IRF-Lucia reporter human monocytes

NF-κB responses in TLR7 overexpressing THP1-Dual™ -derived cells

IRF responses in TLR7 overexpressing THP1-Dual™ -derived cells

IL-20 & IL-24 Reporter HEK 293 Cells

STAT3-SEAP reporter cells

Dose-response of HEK-Blue™ IL-20 cells to recombinant cytokines

Inhibition of hIL-24 signaling in HEK-Blue™ IL-20 cells

IL-21 Reporter HEK 293 Cells

STAT3-SEAP reporter cells

Dose-response of HEK-Blue™ IL-21 cells to recombinant IL-21 cytokines

Response of HEK-Blue™ IL-21 to a panel of cytokines

Dose-dependent inhibition of IL-21 signaling using Avizakimab biosimilar

NF-κB and ISG Dual Reporter HEK 293 Cells - HEK-Dual™ RNA-Null Cells

NF-κB-SEAP & IRF-Lucia Reporter Cells - TLR3, RIG-I & MDA-5 deficient

Human RIG-I, MDA5, and TLR3 expression (Western blot)

Functional validation of HEK-Dual™ RNA-Null cells (NF-κB responses)

Functional validation of HEK-Dual™ RNA-Null cells (IRF responses)

TNF-α Dual Reporter HEK 293 Cells

NF-κB-SEAP & IL-8-Lucia reporter cells

Cellular response to human TNF-α

HEK-Blue-Lucia™ TNF-α specificity

Human TLR9 Dual Reporter HEK 293 Cells (NF-κB)

NF-κB-SEAP & KI-[IL-8]Lucia reporter cells

NF-kB - SEAP response

NF-κB (IL-8) - Lucia response

Mouse TLR7 Dual Reporter HEK 293 Cells

NF-κB-SEAP & KI-[IL-8]Lucia reporter cells

NF-κB - SEAP response

IL-8 - Lucia response

Human ACE2 & TMPRSS2 expressing HEK293 Cells

Human ACE2-expressing reporter Cells

Validation of ACE2 overexpression by qRT-PCR

Validation of hACE2 surface expression by FACS

Infection of HEK-Blue™ hACE2 cells by SARS-CoV-2 Spike pseudotyped lentiviral particles

ACE2 and TMPRSS2 overexpression by RT-qPCR

ACE2 overexpression by FACs

Infection with Spike-pseudotyped lentiviral particles

Assessing cell fusion with 293-hMyD88-Spike Cells

Human MD2-CD14-TLR4/TLR4-KO Dual Reporter THP-1 Cell Lines

Two cell lines (TLR4-OE or TLR4-KO) - NF-κB-SEAP & IRF-Lucia reporter monocytes

Functional validation of NF-κB response

NF-κB responses after stimulation with rough or smooth LPS

Functional validation of IRF response

IRF responses after stimulation with rough or smooth LPS

PCR validation of TLR4 KO in THP1-Dual™ MD2-CD14 KO-TLR4 cells

Human MDA5-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of MDA5 knockout

Functional validation of MDA5 knockout (IRF response)

Functional validation of MDA5 knockout (NF-κB response)

Oxidative Stress ARE Lucia Reporter Cells

ARE-Lucia & ACP5 reporter cells (Nrf2 KEAP1 Pathway)

Oxidative stress induction in HEK-Lucia-Star™ ARE cells

Dose-dependent decrease of oxidative stress response upon antioxidant treatment

Human TLR9 Dual Reporter HEK 293 Cells (NF-κB & IRF)

NF-κB-SEAP & IRF-Lucia reporter cells

NF-κB responses of HEK-Blue™ hTLR9 vs. HEK-Dual™ hTLR9

NF-κB responses in hTLR9-expressing HEK-Dual™ -derived cells

IRF responses in hTLR9-expressing HEK-Dual™-derived cells

Tet-Inducible Gene Expression HEK 293 Cells

Tet-on human embryonic kidney cells

No expression leakage of protein of interest

Doxycycline-mediated gene expression in HEK-RepTor™ cells

Inducible GSDMD-Nter expression

Conditional GSDMD-mediated cell death

NF-κB and ISG Dual Reporter HEK 293 Cells - HEK-Dual™ Cells

NF-κB-SEAP and IRF-Lucia Reporter Cells

NF-κB response of HEK-Dual™ cells to various PRR agonists and cytokines

IRF response of HEK-Dual™ cells to various PRR agonists and cytokines

Human TLR3 Dual Reporter HEK 293 Cells (RIG-I & MDA5 deficient)

NF-κB-SEAP and IRF-Lucia reporter cells

Validation of TLR3 overexpression (Western blot)

Functional validation of HEK-Dual™ RNA-TLR3 cells (NF-κB responses)

Functional validation of HEK-Dual™ RNA-TLR3 cells (IRF responses)

NF-κB and IRF dose responses of HEK-Dual™ RNA-hTLR3 cells

Human TLR2 Dual Reporter HEK 293 Cells

NF-κB-SEAP & KI-[IL-8]-Lucia reporter cells

NF-κB - SEAP response

NF-κB (IL-8) - Lucia response

NF-κB Dual Reporter HEK 293 Cells - HEK-Blue-Lucia™ Null Cells

NF-κB-SEAP & -Lucia Reporter Cells

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Human STING-KI Dual Reporter THP-1 Cell Lines

Five KI-STING variants (R232, H232, M155, S154, A162) - NF-κB-SEAP & IRF-Lucia reporter monocytes

NF-κB responses in THP1-Dual™ KI-hSTING-R232 and H232 cells

IRF responses in THP1-Dual™ KI-hSTING-R232 and H232 cells

NF-κB responses in THP1-Dual™ KI-hSTING-M155 and S154 SAVI cells

IRF responses in THP1-Dual™ KI-hSTING-M155 and S154 SAVI cells

NF-κB responses in THP1-Dual™ KI-hSTING-A162 cells

IRF responses in THP1-Dual™ KI-hSTING-A162 cells

Human TLR3 Dual Reporter THP-1 Cells

TLR3-OE - NF-κB-SEAP & IRF-Lucia reporter human monocytes

Functional validation of NF-κB response

Functional validation of IRF response

G-CSF Reporter HEK 293 Cells

STAT3-SEAP reporter cells

Validation of GCSFR expression

Cellular response to G-CSF

G-CSF signaling inhibition

HEK-Blue™ G-CSF specificity