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Poly(I:C) (HMW) Cy5 - TLR3 agonist

Cy5-labeled poly(I:C) (HMW)

Validation of Cy5 fluorescent labeling by fluorescence microscopy

Validation of Cy5 fluorescent labeling by flow cytometry

Dose-dependent activation of TLR3 with Poly(I:C) Cy5

Poly(I:C) (HMW) Cy3 - TLR3 agonist

Cy3-labeled poly(I:C) (HMW)

Validation of Cy3 fluorescent labeling by flow cytometry

Validation of Cy3 fluorescent labeling by fluorescence microscopy

Dose-dependent activation of TLR3 with Poly(I:C) Cy3

Poly(I:C) (LMW) Rhodamine - TLR3 Agonist

Rhodamine-labeled poly(I:C) (LMW)

Dose-dependent response to Poly(I:C) (LMW) Rhodamine in HEK-Blue™ hTLR3 cells

Poly(I:C) (HMW) Biotin -TLR3 Agonist

Biotin-labeled poly(I:C) (HMW)

TLR3 activation by Poly(I:C) HMW Biotin

Binding of Poly(I:C) HMW Biotin to TLR3

Poly(I:C) (LMW) / LyoVec™ - RIG-I/MDA-5 Agonist

dsRNA - complexed with transfection reagent

Dose-dependent interferon regulatory factor (IRF) response to Poly(I:C) (LMW) / LyoVec™ in A549-Dual™ cells.

Poly(I:C) (HMW) / LyoVec™ - RIG-I/MDA5 Agonist

LyoVec™ complexed

Dose-dependent interferon regulatory factor (IRF) response to Poly(I:C) (HMW) / LyoVec™ in A549-Dual™ cells.

Poly(A:U) - TLR3 Agonist

Polyadenylic-polyuridylic acid

Poly(I:C) (HMW) Fluorescein - TLR3 Agonist

Fluorescent-labeled poly(I:C) (HMW)

Dose-dependent response to Poly(I:C) (HMW) Fluorescein in HEK-Blue™ hTLR3 cells

Poly(I:C) (HMW) Rhodamine - TLR3 Agonist

Rhodamine-labeled poly(I:C) (HMW)

Dose-dependent response to Poly(I:C) (HMW) Rhodamine in HEK-Blue™ hTLR3 cells

Poly(I:C) LMW - TLR3 Agonist

Low molecular weight polyinosine-polycytidylic acid

Dose-dependent activation of TLR3

Poly(I:C) HMW - TLR3 Agonist

High molecular weight polyinosine-polycytidylic acid

Dose-dependent activation of TLR3

NexaVant™ - TLR3 Agonist

Synthetic double stranded RNA

Molecular weight of NexaVant™ (agarose gel)

Comparison of TLR3 ligands (NF-κB and IRF responses)

NF-κB and IRF dose-responses of HEK-Dual™ hTLR3 cells