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#Custom Services

Custom Cell Line Development Service

Our custom cell line development service is designed to support your specific experimental goals

Overexpression confirmation

Biological activity validation

Stability testing

#Custom Services

PRR Compound Screening and Profiling

Our screening service can assess activation or inhibition of innate immune pathways by pattern recognition receptors

Level 1 Compound Profiling Example Figure

Level 2 Compound Dose Response Example Figure

#Custom Services

Custom Cloning Service

Specialized plasmids designed to meet your unique experimental needs

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Recombinant human G-CSF protein - Bioactive cytokine

Recombinant cytokine, source: E. coli

Recombinant human G-CSF detection by SDS-PAGE

Cellular response to human G-CSF

G-CSF signaling inhibition

Recombinant human IL-9 protein - Bioactive cytokine

Recombinant cytokine, source: CHO cells

Human IL-9 SDS-PAGE analysis

Dose-response of HEK-Blue™ IL-9 cells to recombinant human IL-9 cytokine

Dose-dependent inhibition of HEK-Blue™ IL-9 cell response using Enokizumab biosimilar

Recombinant human IFN-β protein - Bioactive cytokine

Recombinant cytokine, source: CHO cells

SDS-PAGE analysis of recombinant human (h)IFN-β

Dose-response of HEK-Blue™ IFN-α/β cells to recombinant human (h)IFN-β

Dose-dependent inhibition of IFN-β signaling in HEK-Blue™ IFN-α/β cells using Anifrolumab biosimilar

Recombinant mouse IL-18 protein - Bioactive cytokine

Recombinant cytokine, source: E. coli

SDS-PAGE analysis of recombinant mouse (m)IL-18

Dose-response of HEK-Blue™ mIL-18 cells to recombinant mouse IL-18

Recombinant human IL-20 protein - Bioactive cytokine

Recombinant cytokine, source: CHO cells

Dose-response of HEK-Blue™ IL-19/IL-20 cells to recombinant human IL-20 cytokine

Human IL-20 SDS-PAGE analysis

Neutralization of cellular response to IL-20 using Fletikumab biosimilar

Recombinant human IL-5 protein - Bioactive cytokine

Recombinant cytokine, source: CHO cells

Dose-response of HEK-Blue™ IL-5 cells to recombinant IL-5

Recombinant human IL-5 detection by SDS-PAGE

Dose-dependent inhibition of IL-5 signaling using Benralizumab biosimilar

#Custom Services

Cytokines Compound Screening

Our profiling service enables the detection of bioactive effects in your samples.

Dose-response of HEK-Blue™-derived cells to compound of interest

Dose-dependent inhibition of HEK-Blue™-derived cell response using the compound of interest

Recombinant human IL-29 (IFNλ1) protein - Bioactive cytokine

Recombinant cytokine, source: CHO cells

Recombinant human IL-29 detection by SDS-PAGE

Dose-response of HEK-Blue™ IFN-λ cells to recombinant IL-29 cytokine

Neutralization of IL-29 signaling using Anti-hIL-29-mIgG1 antibody

Recombinant human APRIL/TNFSF13 protein - Bioactive cytokine

Recombinant cytokine, source: HEK293 cells

SDS-PAGE analysis of recombinant human APRIL

Dose-response of HEK-Blue™ BCMA cells to recombinant human APRIL

Dose-dependent inhibition of HEK-Blue™ BCMA cell response using Sibeprenlimab biosimilar

Recombinant human BAFF/TNFSF13B/BLyS protein - Bioactive cytokine

Recombinant cytokine, source: CHO cells

SDS-PAGE analysis of recombinant human BAFF

Dose-response of HEK-Blue™ BCMA cells to recombinant human BAFF

Dose-dependent inhibition of HEK-Blue™ BCMA cell response using Belimumab biosimilar

#Inflammasome Ligands

Cholesterol Crystals - NLRP3 Inflammasome Inducer

CAS number 57-88-5

Cholesterol Crystals structure invivogen

Microscopic analysis of Cholesterol Crystals

NLRP3 inflammasome activation by cholesterol crystals

Recombinant human TSLP protein - Bioactive cytokine

Recombinant cytokine, source: CHO cells

Recombinant human TSLP detection by SDS-PAGE

HEK-Blue™ TSLP cellular response to recombinant human TSLP

Recombinant human TL1A/TNFSF15 protein - Bioactive cytokine

Recombinant cytokine, source: CHO cells

Recombinant human TL1A detection by SDS-PAGE

HEK-Blue™ TL1A cellular response to recombinant human TL1A

Dose-dependent inhibition of HEK-Blue™ TL1A cell response using Tulisokibart biosimilar

Recombinant human IL-33 protein - Bioactive cytokine

Recombinant cytokine, source: E. coli

Recombinant human IL-33 detection by SDS-PAGE

HEK-Blue™ IL-33 cellular response to recombinant human IL-33

Neutralization of IL-33 signaling using Astegolimab biosimilar

Recombinant human IL-31 protein - Bioactive cytokine

Recombinant cytokine, source: E. coli

Recombinant human IL-31 detection by SDS-PAGE

HEK-Blue™ IL-31 cellular response to recombinant human IL-31

Neutralization of hIL-31 signaling using Nemolizumab

Recombinant human IL-11 protein - Bioactive cytokine

Recombinant cytokine, source: CHO cells

Detection of IL-11 by SDS-PAGE

Dose-response of HEK-Blue™ IL-11 cells to recombinant human IL-11

Recombinant human IL-17A protein - Bioactive cytokine

Recombinant cytokine, source: CHO cells

Recombinant human IL-17A detection by SDS-PAGE

HEK-Blue™ IL-17 cellular response to human and mouse IL-17A