NexaVant™
NexaVant™ | Unit size | Cat. code | Docs | Qty | Price |
---|---|---|---|---|---|
TLR3 agonist - dsRNA-based |
100 µg |
tlrl-nvt |
You may also need : Human TLR3 Reporter HEK293 Cells (NF-κB and IRF) | View more associated products ▼
TLR3 agonist - NexaVant™ (NVT)
InvivoGen provides NexaVant™, a double-stranded (ds) RNA-based TLR3 agonist and promising vaccine adjuvant. NexaVant™ (NVT) is a synthetic dsRNA of 424 base pairs produced by performing PCR-coupled bidirectional in vitro transcription of a viral nucleotide segment using T7 RNA polymerase technology.
NexaVant™ displays high purity (≥ 95%) and molecular homogeneity, therefore overcoming various obstacles of currently available dsRNA-based adjuvant candidates, including Poly(I:C) [1]. It induces NF-κB and IRF responses in HEK-Dual™ hTLR3 cells stronger than Poly(A:U), although it is less potent than Poly(I:C) HMW (see figures). Moreover, it does not trigger serious toxicity in preclinical studies [1].
InvivoGen also offers NexaVant™ VacciGrade™, a high-quality pre-clinical grade suited for in vivo studies.
Key features
- Potent TLR3 agonist and vaccine adjuvant
- Highly pure (≥ 95%) and stable
- Ready-to-use liquid
- Batch-to-batch consistency
- Each lot is functionally tested
- High-quality pre-clinical NexaVant™ VacciGrade™ is also available
NexaVant™ is a trademark that belongs to the NA Vaccine Institute.
NexaVant™ is for research purposes only; not for human or veterinary use.
References:
1. Ko KH, et al., 2023. A novel defined TLR3 agonist as an effective vaccine adjuvant. Front Immunol. ;14:1075291.
Back to the topSpecifications
Description: TLR3 agonist
CAS Number: 2839526-76-8
Quantity: 100 µl
Concentration: 1 mg/ml
Buffer composition: 10mM Phosphate Buffer pH 7.2
Working concentration: 0.1 - 1000 µg/ml
A260/A280 ratio: 1.8 ~ 2.2
Size: 424 bp
Quality control:
- Purity: ≥95%
- Each lot is functionally tested using cellular assays
- The absence of bacterial contamination (lipoproteins & endotoxins) has been confirmed using HEK-Blue-Lucia™ hTLR2 and HEK-Blue-Lucia™ mTLR4 cells
Contents
- 100 µg of NexaVant™, provided as a 100 µl colorless, transparent liquid.
NexaVant™ is shipped at room temperature (RT).
Upon receipt, store at 4°C. NexaVant™ is stable at RT. However, to avoid contamination, we recommend to keep aliquots at 4°C for short-term storage or -20°C for long-term storage.
The product is stable for up to 1 year when properly stored.
Avoid repeated freeze-thaw cycles.
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