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DECTIN-1

pUNO1-bDectin1a Unit size Cat. code Docs Qty Price
pUNO1 bearing the bovine DECTIN1 gene, isoform_1
20 µg
puno1-bdectin1a
+-
$371.00
pUNO1-bDectin1b Unit size Cat. code Docs Qty Price
pUNO1 bearing the bovine DECTIN1 gene, isoform_2
20 µg
puno1-bdectin1b
+-
$371.00
pUNO1-hDectin1a Unit size Cat. code Docs Qty Price
pUNO1 bearing the human DECTIN1 gene, isoform_1 (longest)
20 µg
puno1-hdectin1a
+-
$371.00
pUNO1-hDectin1b Unit size Cat. code Docs Qty Price
pUNO1 bearing the human DECTIN1 gene, isoform_2 (major variant B)
20 µg
puno1-hdectin1b
+-
$371.00
pUNO1-mDectin1a Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse DECTIN1 gene, isoform_1
20 µg
puno1-mdectin1
+-
$371.00
pUNO1-mDectin1b Unit size Cat. code Docs Qty Price
pUNO1 bearing the mouse DECTIN1 gene, isoform_2 (in RAW cell lines)
20 µg
puno1-mdectin1b
+-
$371.00

Alias : CLEC7A, CLECSF12, CD369

 

Dectin-1
C-type lectin domain family 7, member A
C-type lectin-like receptor superfamily 12B

 

Dectin-1 is a C-type lectin expressed on phagocytic cells, including macrophages and neutrophils, that recognizes and responds to live fungal pathogens.
Dectin-1 mediates both the internalization and cellular responses to beta-glucan containing particles such as Zymosan, a cell wall preparation of Saccharomyces cerevisiae, through unique mechanisms [1]. Zymosan is also recognized by TLR2/TLR6 heterodimers which signaling mediates the activation of NF-kB and the production of inflammatory cytokines. Recent data suggest that Dectin-1 and TLR2/TLR6 signaling combine to enhance the responses triggered by each receptor [2,3].

1. Herre J. et al., 2004. The role of dectin-1 in antifungal immunity. Crit Rev Immunol. 24(3):193-204.
2. Gantner BN. et al., 2003. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J.Exp. Med. 197(9):1107-17.
3. Mukhopadhyay S. et al., 2004. The potential for Toll-like receptors to collaborate with other innate immune receptors. Immunology.112(4):521-30.

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Specifications

Bovine DECTIN1 isoform_1 (pUNO1-bDectin1a)

ORF size : 744 bp
Subclone : AgeI - NheI

Bovine DECTIN1 isoform_2 (pUNO1-bDectin1b)

ORF size : 606 bp
Subclone : AgeI - NheI

Human DECTIN1 isoform 1 (longest) (pUNO1-hDectin1a)

ORF size : 744 bp
Subclone : AgeI - NheI

Human DECTIN1 isoform 2 (major variant B) (pUNO1-hDectin1b)

Genbank : NM_022570.4
ORF size : 606 bp
Subclone : AgeI - NheI

Mouse DECTIN1 isoform_1 (pUNO1-mDectin1a)

ORF size : 735 bp
Subclone : BspHI - NheI

Mouse DECTIN1 isoform_2 (pUNO1-mDectin1b)

ORF size : 600 bp
Subclone : BspHI - NheI

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Contents

- 20 µg of lyophilized DNA.
- 4 pouches of E. coli Fast-Media® Blas (2 TB and 2 Agar)
- 1 ml blasticidin at 10 mg/ml

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Citations

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