pFUSE-hIgG2e1-Fc1
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Cat.code:
pfc1-hg2e1
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ABOUT
pFUSE-hIgG2e1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG2 heavy chain mutated K322A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG2e1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Reference
Idusogie EE. et al., 2000. Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc. J Immunol. 164(8):4178-84.
All products are for research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
In vitro transfection, Fc-fusion protein generation
In vitro transfection
Plasmid construct is confirmed by restriction analysis and full-length open reading frame (ORF) sequencing.
Mutation: K322A
Characteristics:
- Reduced binding to C1q
- Reduced CDC
CONTENTS
Contents
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Product:pFUSE-hIgG2e1-Fc1
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Cat code:pfc1-hg2e1
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Quantity:20 µg
1 ml of Zeocin® (100 mg/ml)
Shipping & Storage
- Shipping method: Room temperature
- Upon receipt, store product at -20 °C.
Storage:
DOCUMENTS
Documents
Technical Data Sheet
Plasmid Sequence
Safety Data Sheet
Certificate of analysis
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