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pFUSE-hIgG2e1-Fc

pFUSE-hIgG2e1-Fc1 Unit size Cat. code Docs Qty Price
20 µg
pfc1-hg2e1
+-
$536.00
pFUSE-hIgG2e1-Fc2 Unit size Cat. code Docs Qty Price
20 µg
pfc2-hg2e1
+-
$536.00

pFUSE-hIgG2e1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG2 heavy chain mutated K322A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.

pFUSE-hIgG2e1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.

Idusogie EE. et al., 2000. Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc. J Immunol. 164(8):4178-84.

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Specifications

Isotype : IgG2 human
Mutation
: K322A
Characteristics:

- Reduced binding to C1q
- Reduced CDC

Both plasmids are selectable with Zeocin™.

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Contents

• 20 μg of lyophilized DNA
• 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar)

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