A concise review about our current knowlegde of the Stimulator of Interferon Gens (STING) protein. Learn about STING activity, STING agonists and signaling inhibitors, STING regulation, genetic variation of STING, and therapeutic targeting of STING.

NLRP3 is the best-described inflammasome sensor and an attractive drug target.

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcriptional factor widely expressed among immune, epithelial, endothelial and stromal cells in barrier tissues

IL-2 plays a dual role as both an immune stimulant and an immune suppressor in the regulation of both the proliferation and survival of T cells.

The antiviral type III interferons or IFN-λ family consisting of IFN-λ1 (IL-29), IFN-λ2 (IL-28A), IFN-λ3 (IL-28B), and IFN-λ4, plays a unique role in defense at mucosal barrier sites.

TLR2 is an important pattern recognition receptor (PRR) in the detection of a range of pathogen-associated molecular patterns (PAMPs) from microbes.

The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer immunotherapy, although complete remission remains limited to a small panel of cancers and patients.

Immune Checkpoint Anti-human Antibodies, ADCC Reporter Cell-Based Assay, Antibody Engineering

Currently, there are no specific therapies approved for the treatment of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2. The first strategy for the treatment of COVID-19 is the repurposing of existing drugs that have already been tested safe in humans.

Toll-like receptors (TLRs) play a pivotal role in the initiation of anti-infectious immune responses. Distinct pathogen-associated molecular patterns (PAMPs) are recognized by different TLRs, at the cell surface or in endosomes.

The design of siRNAs and short hairpin siRNAs (shRNAs) remains an empirical process since the molecular mechanisms underlying RNAi are not yet sufficiently understood to allow for the rational design of siRNAs.

Dectin-1 is a recently discovered pattern-recognition receptor that plays an important role in antifungal innate immunity. Dectin-1, which is expressed on phagocytes, is a specific receptor for β-glucans.

Toll-like receptor 9 (TLR9) senses unmethylated CpG dinucleotides, a hallmark of microbial DNA, that can be mimicked by synthetic oligonucleotides containing CpG motifs (CpG ODNs).

Viral infections induce a strong innate immune response characterized by the rapid production of type I interferons (IFN α/β) leading to the inhibition of virus replication.

Bacterial lipopolysaccharide (LPS) is the major structural component of the outer wall of all Gram-negative bacteria and a potent activator of the immune system.

RNA interference (RNAi) has become a powerful tool to uncover gene function and is evolving as a new therapeutic modality.

TLR7 and TLR8 are phylogenetically and structurally related. TLR7 is predominantly expressed in lung, placenta, and spleen, while TLR8 is predominantly expressed in lung and peripheral blood leukocytes, in particular monocytes.