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Human NLRP3-KO THP-1 Cells

NLRP3-KO monocytes

Validation of NLRP3 KO in THP1-KO-NLRP3 cells

Absence of mature IL-1β secretion in THP1-KO-NLRP3 cells

Absence of pyroptosis in THP1-KO-NLRP3 cells (LDH read-out)

Mouse STING-KI Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of mSTING knockin by PCR

Validation of mSTING knockin by Western blot (WES by Protein Simple)

IRF activation (Lucia luciferase reporter)

NF-kB activation (SEAP reporter)

Human IRF3-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of IRF3 knockout by PCR

Validation of IRF3 knockout by Western blot (Wes™)

2'3'-cGAMP-induced IRF and NF-κB responses in THP1-Dual™-derived cells

RNA-induced IRF and NF-κB responses in THP1-Dual™-derived cells

Cytokine or LPS-induced IRF and NF-κB responses in THP1-Dual™-derived cells

Human TBK1-KO Dual Reporter THP-1 Cells

NF-κB-SEAP & IRF-Lucia reporter monocytes

Validation of TBK1 knockout by Western blot (Wes™)

2’3’-cGAMP-induced IRF and NF-κB responses in THP1-Dual-derived cells

RNA-induced IRF and NF-κB responses in THP1-Dual-derived cells

Cytokine or LPS-induced IRF and NF-κB responses in THP1-Dual-derived cells

Human TLR4-KO Dual Reporter THP-1 Cells

NF-κB-SEAP and IRF-Lucia reporter monocytes

PCR validation of TLR4 KO

NF-κB responses in THP1-Dual™ KO-TLR4 cells

IRF responses in PMA-differentiated THP1-Dual™ KO-TLR4 cells

Human TLR2-KO Dual Reporter THP-1 Cells

NF-κB-SEAP and IRF-Lucia reporter monocytes

Validation of TLR2 KO

NF-κB responses in THP1-Dual™ KO-TLR2 cells

IRF responses in THP1-Dual™ KO-TLR2 cells

Human TLR9 Dual Reporter THP-1 Cells

NF-κB-SEAP and IRF-Lucia reporter monocytes

Validation of TLR9 overexpression

Validation of the NF-κB and IRF reporter systems in THP1-Dual™ hTLR9 cells

NF-κB and IRF responses to TLR9 agonists in THP1-Dual™ hTLR9 cells

Human HMGB1-Lucia Reporter THP-1 Cells

Pyroptosis & Necroptosis reporter monocytes

Evaluation of inflammasome mediated-pyroptosis

Human LC3B Reporter THP-1 Cells

RFP::GFP::LC3-OE reporter monocytes

Detection of autophagic fluorescent puncta

Human VISTA-expressing Raji Cells

Human lymphoblast cells - ADCC VISTA Target Cells

VISTA is expressed by Raji-hVISTA cells

ADCC assay with Raji-hVISTA cells

Control Raji Cells

Human lymphoblast cells - ADCC CD19/CD20/Control Target Cells

ADCC assay using various anti-human CD20 (Rituximab) antibody isotypes and Raji-Null target cells

ADCC induction on antigen-expressing Raji cells and Raji-Null control target cells

Human PD-L1-expressing Raji Cells

Human lymphoblast cells - ADCC PD-L1 Target Cells

Validation of the expression of human PD-L1 by Raji-hPD-L1 cells

Comparison of ADCC potency for native and engineered anti-human PD-L1 antibody isotypes

Human PD-1-expressing Raji Cells

Human lymphoblast cells - ADCC PD-1 Target Cells

PD-1 is expressed by Raji-hPD-1 cells

ADCC assay using various anti-human PD-1 (Nivolumab) antibody isotypes and Raji-hPD-1 target cells

Human CTLA4-expressing Raji Cells

Human lymphoblast cells - ADCC CTLA-4 Target Cells

Validation of the expression of human CTLA-4 by Raji-hCTLA4 cells.

ADCC assay using various anti-human CTLA-4 (Ipilimumab) antibody isotypes and Raji-hCTLA4 target cells

Human IP10-KI ISG Reporter THP-1 Cells

IRF-Lucia reporter monocytes

Evaluation of CXCL10 (IP10) induction

CXCL10 is a marker of M1 macrophages

Evaluation of NF-κB expression

Human Gasdermin D-KO THP-1 Cells

GSDMD-KO monocytes

Validation of GSDMD Knockout (KO)

Altered pyroptosis of THP1-KO-GSDMD cells

Control Reporter THP-1 Cells - THP1-Null2 Cells

Control monocytes

Inflammasome responses in THP1-Null2 cells

HER2-expressing Raji Cells

Human lymphoblast cells - ADCC HER2 Target Cells

Validation of the expression of HER2 by Raji-HER2 cells.

Comparison of ADCC potency for native and engineered anti-HER2 antibody isotypes.

ISG Reporter THP-1 Cells (Lucia®)

IRF-Lucia reporter monocytes

IRF response of THP1-Lucia™ ISG cells