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pFUSE-hIgG4-Fc

Product Unit size Cat. code Docs. Qty. Price

pFUSE-hIgG4-Fc1

Fc-fusion protein expression plasmid - Human IgG4

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20 µg

pfuse-hg40fc1
+-
$684

pFUSE-hIgG4-Fc2

Fc-fusion protein expression plasmid - Human IgG4 with IL2ss

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20 µg

pfuse-hg40fc2
+-
$684

Fc-fusion protein expression plasmid - Human IgG4

pFUSE-hIgG4-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG4 heavy chain and the hinge region.

The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.

Human IgG4 displays low ADCC and CDC.

pFUSE-hIgG4-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.

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Specifications

Isotype : IgG4 human

Effector Activities : ADCC+/-, CDC-

Protein A binding: ++++

Protein G binding: ++++

Both plasmids are selectable with Zeocin™.

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pFUSE Contents

  • 20 µg of lyophilized DNA
  • 1 ml of Zeocin® (100 mg/ml)

room temperature Product is shipped at room temperature

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Citations

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