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pFUSE-hIgG1e9-Fc

pFUSE-hIgG1e9-Fc1 Unit size Cat. code Docs Qty Price
20 µg
pfc1-hg1e9
+-
$536.00
pFUSE-hIgG1e9-Fc2 Unit size Cat. code Docs Qty Price
20 µg
pfc2-hg1e9
+-
$536.00

pFUSE-hIgG1e9-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated S239D/I332E/G236A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.

pFUSE-hIgG1e9-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.

Richards JO,. et al., 2008. Optimization of antibody binding to FcgammaRIIa enhances macrophage phagocytosis of tumor cells. Mol Cancer Ther. 7(8):2517-27.

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Specifications

Isotype: IgG1 human
Mutations: S239D/I332E/G236A
Characteristics:
- Increased FcγRIIa/FcγRIIb ratio
- Increased macrophage phagocytosis

Both plasmids are selectable with Zeocin™.

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Contents

• 20 μg of lyophilized DNA
• 4 pouches of E. coli Fast-Media® Zeo (2 TB and 2 Agar)

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