Human IL-17a Antibody (clone 7G11)

Mouse IgG1 - Hybridoma

ABOUT

Anti-hIL-17a-IgG is a neutralizing monoclonal antibody specific for human IL-17a.

Interleukin 17a (IL-17a) is a pro-inflammatory cytokine. Interleukin 17A (IL-17A), a pro-inflammatory cytokine, that belongs to a family of six cytokines; IL-17A, IL-17B, IL-17C, IL-17D, IL-E (also known as IL-25) and IL-17F [1]. IL-17A binds a heterodimeric receptor (IL-17RA/IL-17RC), which recruits the adaptor Act1 leading to TRAF6 ubiquitylation, triggering a signaling cascade that results in NF-kB activation, a key regulator of innate immunity [2]. Although this cytokine exerts a protective role against many pathogens, the overproduction of IL-17A is associated with autoimmune diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease; making this cytokine a pertinent target for monoclonal antibodies [3].

Anti-hIL-17a-IgG has been selected for its ability to efficiently neutralize the biological activity of hIL-17a.

This antibody is produced in hybridomas and purified by affinity chromatography.

 

References:

1. Gu C. et al., 2013. IL-17 family: cytokines, receptors and signaling. Cytokine. 64(2):477- 85
2. Qu F. et al., 2012. TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation. Mol Cell Biol. 32(19):3925-37.
3. Onishi RM. & Gaffen SL., 2010. Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology. 129(3):311-21.

All products are for research use only, and not for human or veterinary use.

SPECIFICATIONS

Specifications

Target

IL-17a

Target species

Human

Species
Human
Isotype
mIgG1
kappa
Clone
7G11
Tag
Tag-free
Source
Hybridoma
Purification
Protein G
Formulation buffer

Sodium phosphate buffer with glycine, saccharose, and stabilizing agents

Preservative
Azide-free
Reconstitution buffer
Sterile water (not provided)
Tested applications

Neutralization assay

Quality control

Each lot is functionally tested and validated.

CONTENTS

Contents

  • Product: 
    Anti-hIL-17a-IgG
  • Cat code: 
    mabg-hil17a-3
  • Quantity: 
    3 x 100 µg

Shipping & Storage

  • Shipping method:  Room temperature
  • Storage:

    • -20°C
    Stability: -20°C for up to 1 year

    Caution:

    • Avoid repeated freeze-thaw cycles

DOCUMENTS

Documents

Anti-hIL-17a-IgG

Technical Data Sheet

Safety Data Sheet

Certificate of analysis

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CUSTOMER SERVICE & TECHNICAL SUPPORT

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