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Anti-hPD-L1-mIgG1

Anti-hPD-L1-mIgG1 Unit size Cat. code Docs Qty Price
Human PD-L1 (atezolizumab) antibody - Mouse IgG1
100 µg
hpdl1-mab9
+-
$325.00
Anti-hPD-L1-mIgG1 InvivoFit Unit size Cat. code Docs Qty Price
Human PD-L1 (atezolizumab) antibody - Mouse IgG1
5 x 1 mg
hpdl1-mab9-5
+-
$2,732.00

Anti-hPD-L1-mIgG1 features the variable region of atezolizumab, a therapeutic monoclonal antibody (mAb) that targets human PD-L1, blocking the interaction with its receptor PD-1. Atezolizumab (formerly known as MPDL3280A) is a fully humanized IgG1 mAb with a modified Fc region designed to limit antibody-dependent cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) [1, 2]. It contains a N298A mutation that eliminates its ability to bind to human Fcγ receptors.
In contrast to nivolumab, a therapeutic mAb that targets only human PD-1, atezolizumab targets both human and mouse PD-L1. To enable studies in mice, the human effectorless Fc domain of atezolizumab has been replaced by the Fc domain of mouse IgG1, an isotype exhibiting low CDC and no ADCC.
Anti-hPD-L1-mIgG1 was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein G.

Anti-hPD-L1-mIgG1 InvivoFit™ is specifically designed for mouse studies:

  • Contains a mouse IgG1 Fc domain to prevent ADAs (anti-drug-antibodies)
  • Provided in a large unit size (5 x 1 mg), larger quantities are available
  • Guaranteed sterile
  • Endotoxin level
  • Low aggregation,
  • No preservative
  • Binding validated by flow cytometry using EL4 cells expressing membrane bound mouse PD-L1

1. Spigel D. et al., 2013. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) [ASCO abstract 8008]. J Clin Oncol. 31(15)(suppl).
2. Herbst RS. et al., 2014. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 515(7528):563-7.

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Specifications

Specificity: Targets cells expressing human and mouse PD-L1
Clonality: Monoclonal antibody
Isotype: Mouse IgG1
Source: CHO cells
Purity: Purified by affinity chromatography with protein G

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Contents

• 100 µg purified anti-hPD-L1-mIgG1 antibody, provided azide-free and lyophilized

or

• 5 x 1 mg purified anti-hPD-L1-mIgG1 InvivoFit™ antibody, provided sterile, endotoxin-free, azide-free and lyophilized

 

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