Human CD20 Antibody - Rituximab IgM isotype

Human IgM

ABOUT

Anti-human CD20 antibody - Human IgM (high CDC effector function)

Anti-hCD20-hIgM is a Rituximab biosimilar antibody with a human IgM isotype for high complement-dependent cytotoxicity (CDC). Rituximab is a mouse/human chimeric monoclonal antibody that targets the CD20 antigen found on the surface of malignant and normal B lymphocytes.

Binding of Rituximab to CD20 results in cell destruction through different mechanisms, including direct signaling of apoptosis, complement activation, and cell-mediated cytotoxicity. Rituximab has been approved by the FDA for the treatment of various lymphoid malignancies, including B-cell non-Hodgkin's lymphoma and B-cell chronic lymphocytic leukaemia.

Anti-hCD20-hIgM was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein L.

All products are for research use only, and not for human or veterinary use.

SPECIFICATIONS

Specifications

Target

CD20

Target species

Human

Applications

Neutralization assay, ELISA, Effector function analysis

Species
Human
Isotype
IgM
Clone
Rituximab
Tag
Tag-free
Source
CHO cells
Purification
Protein L
Preservative
Azide-free
Purity
≥ 95 %
Appearance (form)
Lyophilized
Reconstitution buffer
Sterile water (not provided)
Endotoxin

Negative (tested using EndotoxDetect™ assay

Tested applications

Flow cytometry

Quality control

Each lot is functionally tested and validated.

CONTENTS

Contents

  • Product: 
    Anti-hCD20-hIgM
  • Cat code: 
    hcd20-mab5
  • Quantity: 
    Custom size

Shipping & Storage

  • Shipping method:  Room temperature

    • Storage:

    • -20°C
    Stability: -20°C for up to 1 year

    Caution:

    • Avoid repeated freeze-thaw cycles

DOCUMENTS

Documents

Anti-hCD20-hIgM

Technical Data Sheet

Safety Data Sheet

Certificate of analysis

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